Product Details
| Product Name:
Tovinontrine |
CAS No.:
2062661-53-2 |
| Purity:
98.14% |
Supply Ability:
10g |
| Release date:
2025/11/09 |
Product Introduction
Bioactivity
| Name | Tovinontrine |
| Description | Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment. It exhibits high efficacy, with IC 50 values of 8.19 nM and 9.99 nM for PDE9A1 and PDE9A2, respectively [1]. |
| In vitro | Tovinontrine (IMR-687) (0.03-10 μM) treatment for 6 hours in erythroid K562 cells increases cGMP in a dose-dependent manner.[1]
IMR-687 (0.1-10 μM) treatment in erythroid K562 cells for 72 hours induces hemoglobin (HbF) in a dose-dependent manner.[1] |
| In vivo | Tovinontrine (IMR-687) (30 mg/kg/day; 30 days) resulted in a more than three-fold increase in the proportion of HbF+ F-cells (8.4% in the vehicle-treated group and 27.3% in the IMR-687 treated group), accompanied by a corresponding two-fold reduction in sickled red blood cells (56.3% in the vehicle-treated group and 24.4% in the IMR-687 treated group).[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 90.0 mg/mL (228.2 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (8.37 mM), Sonication is recommended.
|
| Keywords | Tovinontrine | PDE9A | IMR687 | IMR 687 |
| Inhibitors Related | Theophylline monohydrate | Pentoxifylline | Diphylline | Acefylline | Roflumilast | Theobromine | Apremilast | Indomethacin | Icariin | Vardenafil hydrochloride | Doxofylline | Sildenafil citrate |
| Related Compound Libraries | Bioactive Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cardiovascular Disease Compound Library | Metabolism Compound Library | Clinical Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States