TRK II-IN-1 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-29 |
Product Details
| Product Name: TRK II-IN-1 | CAS No.: 2904690-41-9 |
| Supply Ability: 10g | Release date: 2025/04/29 |
Product Introduction
Bioactivity
| Name | TRK II-IN-1 |
| Description | TRK II-IN-1 is a potent type II inhibitor of tropomyosin receptor kinases (TRK), with IC50 values of 3.3, 6.4, 4.3, and 9.4 nM against TRKA, TRKB, TRKC, and the mutant TRKA G667C, respectively. It also exhibits IC50 values of 1.3 nM against FLT3, 9.9 nM against RET, and 71.1 nM against VEGFR2. TRK II-IN-1 primarily serves as a research tool for studying TRK-driven cancers [1]. |
| In vitro | TRK II-IN-1 (compound 12d) demonstrated significant kinase inhibition, achieving over 90% inhibition of VEGFR2, RET, and FLT3, and approximately 70% inhibition of Kit, CSF1R, DDR1, and DDR2 at 1 μM [1]. The compound effectively inhibited growth in Ba/F3 cell lines Ba/F3-CD74-TRKA, Ba/F3-ETV6-TRKB, and Ba/F3-ETV6-TRKC at 72 hours, with IC50 values of 26.1, 44.7, and 15.7 nM respectively [1]. It also suppressed proliferation in Ba/F3 cells with various TRK fusion proteins (wild type and mutant), showing IC50 values of 2.6-143.3 nM [1]. TRK II-IN-1 induced apoptosis in Ba/F3-CD74-TRKA and Ba/F3-CD74-TRKA G667C cells within 48 hours at concentrations of 0.4-500 nM [1], caused G0/G1 cell cycle arrest in the same cells over 24 hours [1], and dose-dependently suppressed phosphorylation of TRKA, TRKA G667C, AKT, ERK, and PLCγ1 after 6 hours of treatment at 0.8-500 nM [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | Trkreceptor | Trk receptor |
| Inhibitors Related | Entrectinib | Larotrectinib sulfate | N-Acetyl-5-hydroxytryptamine | Selitrectinib | Sitravatinib | SP600125 | Amitriptyline hydrochloride | 7,8-Dihydroxyflavone | Tepotinib | Diosmetin | GW 441756 | ALE-0540 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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