Product Details
| Product Name:
TTP-8307 |
CAS No.:
950225-08-8 |
| Purity:
98.95% |
Supply Ability:
10g |
| Release date:
2025/12/09 |
Product Introduction
Bioactivity
| Name | TTP-8307 |
| Description | TTP-8307 is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses, and inhibits coxsackievirus B3 and poliovirus by interfering with viral RNA synthesis.TTP-8307 can be used in the study of viral infections. |
| In vitro | TTP-8307 targeted non-structural protein 3A and inhibited the replication of enterovirus B3 (CVB3 Nancy) with an EC50 of 1.2 μM. In addition, TTP-8307 inhibited the replication of three Sabin poliovirus strains, as well as enteroviruses A16 and A21, with EC50s of 0.85 and 5.34 μM, respectively.Meanwhile, TTP-8307 inhibited the replication of human rhinoviruses (HRVs) 2, 29, 39, 45, 63 and 85 was also inhibitory. Mutations in non-structural protein 3A caused resistance to TTP-8307, a novel enterovirus replication inhibitor.
In addition, TTP-8307 inhibits OSBP-dependent viruses, including encephalomyelitis virus (EMCV) and hepatitis C virus (HCV). [1][2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 3.3 mg/mL (7.56 mM), Sonication is recommeded.
DMSO : 80 mg/mL (183.28 mM), Sonication is recommended.
|
| Keywords | TTP-8307 | TTP 8307 | RNASynthesis | RNA Synthesis | HCVProtease | HCV Protease | HCV | DNASynthesis | DNA/RNA SynthesisProtease | DNA Synthesis |
| Inhibitors Related | 5-Fluorouracil | Phenytoin sodium | Adenine hemisulfate | Methyl 2-amino-5-bromobenzoate | Deferiprone | Guanidine hydrochloride | Methotrexate disodium | L-Lysine | Adenine | Ofloxacin | Carbazole | Thymidine |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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