Tubulin polymerization-IN-36 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: Tubulin polymerization-IN-36 | CAS No.: 2011784-91-9 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | Tubulin polymerization-IN-36 |
| Description | Tubulin polymerization-IN-36 is able to be used in cancer research, for example, lymphomas. Tubulin polymerization-IN-36 binds to the colchicine site of tubulin and inhibits colchicine binding, that is an inhibitor of tubulin polymerization with IC50 of 2.8 μΜ[1]. |
| In vitro | Tubulin polymerization-IN-36 (compound 2e) exhibits notable biological activity by reducing lymphoma cell proliferation to below 50% at a concentration of 1 μM over 72 hours and demonstrating cytotoxicity against MCF-7 cells with an IC50 of 0.29 μM. It induces apoptosis and arrests VL51 and MINO cells in the G2/M phase at concentrations between 50 and 500 nM over 24 to 72 hours. Additionally, it inhibits colchicine’s tubulin binding by 88% at 5 μM. Cell proliferation assays on VL51, MINO, HBL1, and SU-DHL-10 cell lines over 72 hours with concentrations up to 10 μM result in 38%, 0.8%, 7.1%, and 30.5% proliferation at 1 μM, respectively, with IC50 values from 0.02 to 0.04 μM. Cell cycle analysis confirms its mechanism by arresting VL51 and MINO cells in the G2/M phase at 50 and 500 nM. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Flubendazole | N-Phenylbenzylamine | Mebendazole | T-900607 | 4-Isopropoxybenzoic acid | Oxfendazole | Methylene Blue | Griseofulvin | Paclitaxel | Benproperine phosphate | 4'-Demethylepipodophyllotoxin | Albendazole |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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