Product Details
| Product Name:
UK-370106 |
CAS No.:
230961-21-4 |
| Supply Ability:
10g |
Release date:
2025/07/18 |
Product Introduction
Bioactivity
| Name | UK-370106 |
| Description | UK-370106 is a potent and highly selective inhibitor of MMP-3 (IC50: 23 nM) and MMP-12 (IC50: 42 nM), effectively inhibiting the cleavage of [3H]-fibronectin by MMP-3 (IC50: 320 nM). |
| In vitro | UK-370106 potency for the inhibition of MMP-13 is 2.3 μM, some 100-fold less potent than its inhibition of MMP-3. UK-370106 is found to be inactive (IC50 > 100 μM) vs zinc metalloproteases PCP and TACE and possesses the following inhibitory potencies vs MMP-2 (IC50 of 34.2 μM), MMP-7 (IC50 of 5.8 μM), MMP-8 (IC50 of 1.75 μM), MMP-9 (IC50 of 30.4 μM) and MMP-14 (IC50 of 66.9 μM)[1]. UK-370106 potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50 of 320 nM)[1]. |
| In vivo | Following intravenous (rat; 2 mg/kg) or topical administration to dermal wounds (rabbit), UK-370106 (compound 7) is rapidly cleared from plasma (t1/2 = 23 min) but slowly from dermal tissue (t1/2 approximately 3 days). Topical administration of UK-370106 for 6 days substantially inhibits MMP-3 ex vivo in a model of chronic dermal ulcers [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | UK-370106 | UK370106 | UK 370106 | MMP-9 | MMP-8 | MMP-7 | MMP-3 | MMP-2 | MMP-14 | MMP-13 | MMP-12 |
| Inhibitors Related | Stigmasterol | Ethyl gallate | Doxycycline (hyclate) | Astragaloside IV | Doxycycline | Edaravone | Glucosamine | Bovine Type II Collagen | Triolein | Arctigenin | Fenofibric acid | Glucosamine sulfate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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