UNC 569 hydrochloride NEW
| Price | $41 | $92 | $148 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-26 |
Product Details
| Product Name: UNC 569 hydrochloride | Purity: 99.93% |
| Supply Ability: 10g | Release date: 2025/10/26 |
Product Introduction
Bioactivity
| Name | UNC 569 hydrochloride |
| Description | UNC 569 hydrochloride is a reversible and ATP-competitive inhibitor of Mer with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC 569 hydrochloride inhibits Axl and Tyro3 with IC50s of 37 nM and 48 nM, respectively. UNC 569 hydrochloride can be used in studies about acute lymphoblastic leukemia and atypical teratoid/rhabdoid tumors. |
| In vitro | UNC 569 hydrochloride inhibits Mer phosphorylation levels with IC50 values of 141 nM and 193 nM in human B-ALL 697 and Jurkat cell lines, respectively. UNC 569 hydrochloride (1 µM) treatment effectively inhibits the activation of Mer and downstream signaling, including the PI3K/AKT and MAPK/ERK pathways. In ALL cell lines, UNC 569 hydrochloride (0.4 -2 µM) induces apoptosis and increases the levels of cleaved Caspase 3 and cleaved PARP[1]. |
| In vivo | In Leukemic zebrafish, UNC 569 hydrochloride (4 µM) induces more than 50% reduction in tumor burden compared with vehicle- and mock-treated fish[1]. UNC 569 hydrochloride has low systemic clearance (19.5 mL/min/kg), high volume of distribution (Vss of 5.83 L/kg), and good oral bioavailability (57%)[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 0.1M HCl : 6 mg/mL (13.86 mM), Sonication and heating are recommended. DMSO : 3.61 mg/mL (8.34 mM), Sonication is recommended. |
| Keywords | UNC-569 Hydrochloride | UNC569 Hydrochloride | UNC 569 Hydrochloride | UNC 569 hydrochloride | Tyro3 | TAMReceptor | TAM Receptor | Mer | AXL | 1350547-65-7 Free base | 1350547-65-7 |
| Inhibitors Related | UNC2025 | Cabozantinib | Gilteritinib | Bemcentinib | TAM-IN-2 | Dubermatinib | Sitravatinib | NCT-503 | Cabozantinib S-malate | G-749 | AXL-IN-13 | BMS 777607 |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Hematonosis Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1980.00/50mg |
VIP2Y
|
TargetMol Chemicals Inc.
|
2025-10-27 | |
| $0.01/1KG |
VIP6Y
|
Career Henan Chemica Co
|
2020-10-28 | |
| $577.00/50μg |
VIP4Y
|
TargetMol Chemicals Inc.
|
2025-08-29 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY