WHI-P180 hydrochloride NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: WHI-P180 hydrochloride | CAS No.: 153437-55-9 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | WHI-P180 hydrochloride |
| Description | WHI-P180 (Janex 3) inhibits RET, KDR and EGFR with IC50 values of 5 nM, 66 nM and 4 μM, respectively. WHI-P180 is a multi-kinase inhibitor. |
| In vivo | WHI-P180 acts as an effective inhibitor of IgE-mediated mast cell responses. In CD-1 (BALB/c) mice, its elimination half-life is below 10 minutes across intravenous (i.v.), intraperitoneal (i.p.), and oral (p.o.) administrations. Systemic clearance rates for WHI-P180 are recorded at 6742 mL/h/kg in CD-1 mice and 8188 mL/h/kg in BALB/c mice. Importantly, administering two consecutive, non-toxic i.p. bolus doses of 25 mg/kg of WHI-P180 suppresses IgE/antigen-induced vascular hyperpermeability in a validated mouse model of passive cutaneous anaphylaxis. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Osimertinib | Sorafenib | Lapatinib | glycine | Regorafenib | Erlotinib | Neratinib | Ethyl cinnamate | Afatinib | Chloramphenicol | Gefitinib | Pazopanib |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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