Withanolide B NEW
| Price | $332 | $932 | Get Latest Price |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: Withanolide B | CAS No.: 56973-41-2 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | Withanolide B |
| Description | Withanolide B, a natural product isolated from Withania somnifera Dunal, promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) via the ERK1/2 and Wnt/β-catenin signalling pathways, thereby enhancing bone healing. Withanolide B exhibits affinity for the catalytic domain of PARP-1. |
| In vitro | Methods: SK-N-SH cells were treated with Withanolide B (10-100 μM, 48 hours), and cell viability was assessed using the MTT assay. Results: The IC50 value of Withanolide B for SK-N-SH cells was 14.84±1.45 μM, indicating that Withanolide B exhibits low toxicity to neuronal cells. [1] |
| In vivo | Methods: By injecting Withanolide B (10 mg/kg) into the bone defect site of the SD rat tibial osteotomy model, the effect of Withanolide B on the osteogenic differentiation of hBMSCs was investigated. Results: Micro-CT scanning and histological analysis demonstrated that Withanolide B significantly promoted the healing of bone defects. [2] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Acetone : 0.8 mg/mL (1.76 mM), Sonication is recommended. DMSO : 2.5 mg/mL (5.5 mM), Sonication is recommended. |
| Keywords | Withanolide B |
| Inhibitors Related | TBHQ | Urea | Lidocaine | Astragaloside IV | 3-Aminobenzamide | Lidocaine hydrochloride | Niraparib | Tauroursodeoxycholate | Olaparib | Benzamide | Nisin Z | Methyl Vanillate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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