Product Details
| Product Name:
YE6144 |
CAS No.:
3065657-02-2 |
| Supply Ability:
10g |
Release date:
2025/12/03 |
Product Introduction
Bioactivity
| Name | YE6144 |
| Description | YE6144 is a prototype IRF5 inhibitor that selectively blocks IRF5 phosphorylation.YE6144 can also inhibit the production of type 1 IFNs (IC50 = 0.09μM). |
| In vitro | Methods: Human HC PBMC and mouse WT splenocytes were treated with YE6144 (1 μM and 3 μM, 30 minutes), and protein expression was detected by Western blotting. Results: YE6144 inhibited the phosphorylation of IRF5 in the above cells. [1] |
| In vivo | Methods: YE6144 (40 mg/kg, subcutaneous injection, single dose) was used to treat NZB/W F1 mice with systemic lupus erythematosus (SLE) and its effects were observed. Results: YE6144 was able to inhibit the progression of autoantibody production in mice. Post-onset treatment also inhibited splenomegaly and renal insufficiency. [1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 55 mg/mL (122.78 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (22.32 mM), Sonication is recommended.
|
| Inhibitors Related | 2',3'-cGAMP sodium | Feeblin | Deucravacitinib | RO8191 | DC-Chol hydrochloride | Icariside I | Allura Red AC | Cridanimod | Actarit | CCCP | 2'-Deoxy-2'-fluorouridine | TNF/IFNγ-IN-1 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States