Zoledronic acid disodium tetrahydrate NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-10-27 |
Product Details
| Product Name: Zoledronic acid disodium tetrahydrate | CAS No.: 165800-07-7 |
| Supply Ability: 10g | Release date: 2025/10/27 |
Product Introduction
Bioactivity
| Name | Zoledronic acid disodium tetrahydrate |
| Description | Zoledronic Acid (Zoledronate) disodium tetrahydrate is a potent third-generation bisphosphonate (BP) with strong anti-resorptive activity, effectively inhibiting osteoclast differentiation and apoptosis, and demonstrating anti-cancer properties [1]. |
| In vitro | Zoledronic Acid disodium tetrahydrate, at concentrations ranging from 0.1 to 1 μM over 48 hours, enhances receptor activator of nuclear factor kB ligand (RANKL) and sclerostin mRNA expressions in osteocyte-like MLO-Y4 cells, as well as increases osteoclastogenesis supporting factor expression from the same cells. It also amplifies RANKL expression through the IL-6/JAK2/STAT3 pathway in MLO-Y4 cells, while inhibiting osteoclast differentiation and function by modulating NF-κB and JNK signaling pathways. At higher concentrations (10-100 μM, over 1 to 7 days), it significantly reduces the viability of MC3T3-E1 cells and promotes apoptosis, inhibiting cell viability through apoptosis induction at the 4-day mark. This compound also hinders the differentiation and maturation of MC3T3-E1 cells at concentrations below 1 μM. Experiments demonstrated reduced cell viability at 10 μM and 100 μM, with a dose- and time-dependent increase in early apoptotic and late apoptotic or necrotic cells at higher concentrations. Western Blot analysis revealed down-regulation of inactive caspase-3 and increased levels of active caspase-3 at 10 and 100 μM. |
| In vivo | Zoledronic Acid disodium tetrahydrate administered intraperitoneally (i.p.) at a dose of 0.05 mg/kg weekly for three weeks enhanced bone mineral density and content in five-week-old C57BL6 mice. At increased doses of 0.5-1 mg/kg, administered in the same manner and duration, the compound not only continued to enhance bone mineral density but also inhibited the functions of both osteoclasts and osteoblasts, as well as bone remodeling, thereby affecting the mechanical properties of bone. These findings underline the dose-dependent effects of Zoledronic Acid disodium tetrahydrate on bone health and remodeling. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Inhibitors Related | Neomycin sulfate | Aceglutamide | Cysteamine hydrochloride | Adipic dihydrazide | Sulfamethoxazole sodium | Terbinafine hydrochloride | Hydroxychloroquine | Metronidazole | Tributyrin | Paeonol | Alginic acid | BES |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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