| Product Identification | Back to Contents | 【Product Name】
(2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine but-2-enedioic acid | 【Synonyms】
(+)-2-(2-((p-Chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine
2-(2-(1-(4-Chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine
Aloginan
Alphamin
Anhistan | 【CAS】
14976-57-9 | 【Formula】
C25H30ClNO5 | 【Molecular Weight】
460.01 | 【EINECS】
239-055-2 | 【RTECS】
UY0704600 | 【RTECS Class】
Drug | 【Beilstein/Gmelin】
4118973 | 【Beilstein Reference】
5-21-01-00115 |
| Physical and Chemical Properties | Back to Contents | 【Appearance】
Colorless to faintly yellow crystalline powder. Odorless. | 【Solubility in water】
Slightly soluble | 【Melting Point】
176 - 180 | 【Boiling Point】
154 (0.02 torr) | 【Usage】
A histamine h1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. |
| First Aid Measures | Back to Contents | 【Ingestion】
Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended. | 【Inhalation】
If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention. | 【Skin】
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. | 【Eyes】
Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. |
| Handling and Storage | Back to Contents | 【Storage】
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage. | 【Handling】
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. |
| Hazards Identification | Back to Contents | 【Inhalation】
Pneumonitis, chest tightness, and wheezing have been reported. | 【Eyes】
Anticholinergic effects, such as prolonged dialation of the pupils, nasal dryness and stuffiness, and mouth and throat dryness, can occur with overdose or therapeutic use. | 【Ingestion】
Overdose may cause anticholinergic effects of ileus and diminished bowel sounds. Nausea, vomiting, and loss of appetite may occur . |
| Exposure Controls/Personal Protection | Back to Contents | 【Personal Protection】
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | 【Respirators】
Use NIOSH/MSHA approved respirator appropriate for exposure of concern. | 【Exposure Effects】
Rapid heart rate is common. Elevated body temperature, abnormally low blood pressure, and elevated blood pressure have been reported. overdose may result in either CNS depression, including coma, or CNS stimulation, such as toxic psychosis. Subsequent seizures are not uncommon, especially in children. A higher incidence of seizures has been reported following pheniramine overdoses. Therapeutic use has been associated with acute dystonic reactions and dyskinesias. In general, there have been few reported teratogenic effects in humans, although animal studies have suggested that certain antihistamines have teratogenic potential. <br>Pyloric stenosis has occurred in infants following maternal use of antihistamines. <br>Small amounts of antihistamines are excreted in breast milk. |
| Fire Fighting Measures | Back to Contents | 【Fire Fighting】
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire. |
| Accidental Release Measures | Back to Contents | 【Small spills/leaks】
Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces. |
|
| Company Name: |
J & K SCIENTIFIC LTD. |
| Tel: |
010-82848833 400-666-7788 |
| Fax: |
86-10-82849933 |
| WebSite: |
http://www.jkchemical.com |
| Company Name: |
Adamas Reagent, Ltd. |
| Tel: |
400-6009262 16621234537 |
| Fax: |
021-64823266 |
| WebSite: |
www.tansoole.com |
|