| Product Identification | Back to Contents | 【Product Name】
2-Acetamido-5-sulfamoyl-1,3,4-thiadiazole | 【Synonyms】
2-Acetamido-5-sulfonamido-1,3,4-thiadiazole
5-Acetamide-1,3,4-thiadiazole-2-sulfonamide
Acetamidothiadiazolesulfonamide
Acetamox
Acetazolamid | 【CAS】
59-66-5 | 【Formula】
C4H6N4O3S2 | 【Molecular Weight】
222.25 | 【EINECS】
200-440-5 | 【RTECS】
AC8225000 | 【RTECS Class】
Drug; Reproductive Effector; Human Data | 【Merck】
13,54 | 【Beilstein/Gmelin】
212994 | 【Beilstein Reference】
4-27-00-08219 |
| Physical and Chemical Properties | Back to Contents | 【Appearance】
White to yellowish-white fine crystalline powder. No odor or taste. | 【Solubility in water】
Insoluble | 【Melting Point】
258-259 | 【Density】
1.771 g/cm3 (20 C) | 【pKa/pKb】
6.80 (pKb) | 【Usage】
Pharmaceutical. |
| First Aid Measures | Back to Contents | 【Ingestion】
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. | 【Inhalation】
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used. | 【Skin】
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. | 【Eyes】
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Handling and Storage | Back to Contents | 【Storage】
Store between 15 and 30C (59 and 86F), in a well-closed container, unless otherwise specified by manufacturer. | 【Handling】
All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. |
| Hazards Identification | Back to Contents | 【Inhalation】
Noncardiogenic pulmonary edema after hydrochlorothiazide ingestion has been reported and is believed to be an idiosyncratic reaction. | 【EC Risk Phrase】
R 61 | 【EC Safety Phrase】
S 45 53 | 【UN (DOT)】
2811 |
| Exposure Controls/Personal Protection | Back to Contents | 【Personal Protection】
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | 【Respirators】
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. | 【Exposure Effects】
in overdose lethargy and coma have been reported in children ingesting thiazide diuretics. Altered mental status, headache, hypertonia, muscle weakness, and seizures may develop secondary to diuretic-induced electrolyte abnormalities. Ototoxicity occurs rarely and is usually reversible. |
| Fire Fighting Measures | Back to Contents | 【Fire Fighting】
Fires involving this chemical can be controlled with a dry chemical, carbon dioxide, or Halon extinguisher. | 【Fire Potential】
This material is probably combustible. |
| Accidental Release Measures | Back to Contents | 【Small spills/leaks】
If you spill this chemical, dampen the solid spill material with 5% ammonium hydroxide, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% ammonium hydroxide to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% ammonium hydroxide followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Stability and Reactivity | Back to Contents | 【Stability】
Sensitive to light. | 【Incompatibilities】
Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents Flammable gases are formed by mixing materials in this group with alkali metals Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides. |
|
| Company Name: |
J & K SCIENTIFIC LTD. |
| Tel: |
010-82848833 400-666-7788 |
| Fax: |
86-10-82849933 |
| WebSite: |
http://www.jkchemical.com |
| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Fax: |
021-67582001/03/05 |
| WebSite: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical |
| Tel: |
021-021-58432009 400-005-6266 |
| Fax: |
021-58436166 |
| WebSite: |
http://www.energy-chemical.com |
| Company Name: |
Capot Chemical Co., Ltd |
| Tel: |
+86 (0) 571 85 58 67 18 |
| Fax: |
0086-571-85864795 |
| WebSite: |
www.capotchem.com |
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