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10-(2-Dimethylamino-1-propyl)phenothiazine hydrochloride(58-33-3)

10-(2-Dimethylamino-1-propyl)phenothiazine hydrochloride(58-33-3)
Product IdentificationBack to Contents
【Product Name】

10-(2-Dimethylamino-1-propyl)phenothiazine hydrochloride
【Synonyms】

Diprasine
Fellozine
N,N-Dimethyl-1-phenothiazin-10-ylpropan-2-amine hydrochloride
Phenergan
Phenothiazine, 10-(2-(dimethylamino)propyl)-, monohydrochloride
【CAS】

58-33-3
【Formula】

C17H20N2S.ClH
【Molecular Weight】

320.89
【EINECS】

200-375-2
【RTECS】

SO8225000
【RTECS Class】

Tumorigen; Drug; Reproductive Effector; Human Data
【Beilstein/Gmelin】

4166397
【Beilstein Reference】

4-27-00-01253
Physical and Chemical PropertiesBack to Contents
【Appearance】

Odorless white to faint yellow crystalline powder. Bitter taste.
【Melting Point】

230
【Heat Of Vaporization】

【Usage】

Treatment allergic symptoms and reactions such as itching, runny nose; sneezing; itchy, watery eyes; hives; and itchy skin rashes. Also used to cause sedation, to assist in controlling postoperative pain, to control nausea and vomiting, and to prevent motion sickness.
First Aid MeasuresBack to Contents
【Ingestion】

DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.
【Inhalation】

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.
【Skin】

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
【Eyes】

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.
Handling and StorageBack to Contents
【Storage】

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
【Handling】

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
Hazards IdentificationBack to Contents
【Ingestion】

See inhalation.
【Inhalation】

Symptoms of exposure to this compound include excitement, sleepiness, convulsions and rigidity. Other symptoms include leukopenia, agranulocytosis, drowsiness, confusion and stupor. Acute transitory myopia may occur. Central nervous system effects may also occur. It may cause an increase in blood pressure, mild hypotension, jaundice, extra-pyramidal reactions and photosensitivity. It may also cause dizziness, central nervous system depression, vomiting, local anesthesia, abdominal pain, diarrhea and dryness of the mouth, throat and nose.
【Skin】

See inhalation.
【Eyes】

See inhalation
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
【Respirators】

Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.
Fire Fighting MeasuresBack to Contents
【Fire Fighting】

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.
【Fire Potential】

This material is probably combustible.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Stability and ReactivityBack to Contents
【Stability】

No data.
【Incompatibilities】

Sensitive to light Incompatible with alkalis and alkaline solutions such as those of aminophylline, soluble barbiturates and phenytoin sodium.
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