ChemicalBook >>Adriamycin>>(1S,3S)-3,5,12-Trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside(23214-92-8)

(1S,3S)-3,5,12-Trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside(23214-92-8)

(1S,3S)-3,5,12-Trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside(23214-92-8)
Product IdentificationBack to Contents
【Product Name】

(1S,3S)-3,5,12-Trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
【Synonyms】

(85-Cis)-10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-methoxy-5,12-Naphthacenedione
(8S)-10-((4S,5S,6S)-4-amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione
ADM
Adriamycin
Adriblastin
Adriblastina
【CAS】

23214-92-8
【Formula】

C27H29NO11
【Molecular Weight】

543.53
【EINECS】

245-495-6
【RTECS】

AV9800000
【RTECS Class】

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Natural Product; Primary Irritant
【Merck】

12,3495
【Beilstein/Gmelin】

1445811
Physical and Chemical PropertiesBack to Contents
【Appearance】

Orange powder.
【Solubility in water】

2%
【Melting Point】

216
【pKa/pKb】

8.33 (pKa)
【Usage】

Medication.
First Aid MeasuresBack to Contents
【Ingestion】

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.
【Inhalation】

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
【Skin】

Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.
【Eyes】

Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.
Handling and StorageBack to Contents
【Storage】

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
【Handling】

Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Hazards IdentificationBack to Contents
【Inhalation】

Causes respiratory tract irritation. May cause allergic respiratory tract irritation. Can produce delayed pulmonary edema.
【Skin】

Doxorubicin has irritant properties. Severe ulceration and necrosis may occur from extravasation.
【Eyes】

Causes eye irritation. May cause chemical conjunctivitis.
【Ingestion】

Nausea, vomiting, and diarrhea may occur.
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
【Respirators】

Respiratory protection should be an adjunct to and not a substitute for engineering controls.<BR>Organic vapor acid gas canister; done in the open, an area away from drafts and traffic
【Exposure Effects】

Prolonged or repeated exposure may cause adverse reproductive effects. Repeated exposure may cause allergic respiratory reaction (asthma). Effects may be delayed. May cause allergic skin reaction in some individuals.
Fire Fighting MeasuresBack to Contents
【Fire Fighting】

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately. Avoid generating dusty conditions. Provide ventilation.
Stability and ReactivityBack to Contents
【Stability】

Stable at room temperature in closed containers under normal storage and handling conditions.
【Incompatibilities】

Strong oxidizing agents.
【Decomposition】

Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.
Company Name: Shanghai jerryxing Biomedical Technology Co., Ltd
Tel: 17721492509
Fax:
WebSite: www.chemicalbook.com/supplier/25749450/
Company Name: Beijing Ouhe Technology Co., Ltd
Tel: 010-82967028 13552068683
Fax: +86-10-82967029
WebSite: http://www.ouhechem.com/
Company Name: JinYan Chemicals(ShangHai) Co.,Ltd.
Tel: 13817811078
Fax: 86-021-50426522,50426273
WebSite: www.jingyan-chemical.com
Company Name: Jia Xing Isenchem Co.,Ltd
Tel: 0573-85285100 18627885956
Fax: 0573-85285100
WebSite: https://www.chemicalbook.com/ShowSupplierProductsList14265/0.htm
Company Name: Chemsky (shanghai) International Co.,Ltd
Tel: 021-50135380
Fax:
WebSite: www.shchemsky.com
Company Name: Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel: +8618575662672 18575662672
Fax: 021 51613951
WebSite: www.sunwaypharm.com
Company Name: Hangzhou Yuhao Chemical Technology Co., Ltd
Tel: 0571-82693216
Fax: +86-571-82880190
WebSite: www.chemyuhao.com
Company Name: Wuhan Haizheng Industry & Trade Development Co. Ltd
Tel: 027-8866 0053/88660577/88660578
Fax: 027-8899 1911
WebSite: www.chemicalbook.com/ShowSupplierProductsList15548/0.htm