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Paclitaxel

Paclitaxel
Product IdentificationBack to Contents
【Product Name】

7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid deriv.
【Synonyms】

7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
NSC 125973
Paclitaxel
Yewtaxan
【CAS】

33069-62-4
【Formula】

C47H51NO14
【Molecular Weight】

853.92
【RTECS】

DA8340700
【RTECS Class】

Drug; Mutagen; Reproductive Effector; Human Data
【Merck】

12,7117
【Beilstein/Gmelin】

1420457
Physical and Chemical PropertiesBack to Contents
【Appearance】

Needles (from aqueous methanol) or fine white powder.
【Melting Point】

213 - 216
【Usage】

Tool in study of structure and function of microtubules.
First Aid MeasuresBack to Contents
【Ingestion】

Get medical aid. Wash mouth out with water.
【Inhalation】

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
【Skin】

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
【Eyes】

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Handling and StorageBack to Contents
【Storage】

Store in a tightly closed container. Store in a dry area. Deep freeze (below -20 C).
【Handling】

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Hazards IdentificationBack to Contents
【Inhalation】

May cause respiratory tract irritation. May be harmful if inhaled.
【Skin】

May cause skin irritation. May be harmful if absorbed through the skin.
【Eyes】

May cause eye irritation and possible damage.
【Ingestion】

May cause irritation of the digestive tract. May be harmful if swallowed.
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
【Exposure Effects】

sensory neuropathy of the hands and feet or mouth and tongue was reported in patients taking paclitaxel or docetaxel. Symptoms include a burning dysesthesia of the feet, numbness, and lancing pain in the back or extremities. Seizures, autonomic neuropathy, motor dysfunction, proximal muscle weakness, and coma have been occasionally described. Optic nerve disturbances have been reported following paclitaxel therapy. Paclitaxel and docetaxel may be maternal and embryo-fetal toxic and are classified as FDA Pregnancy Category D. <br>Breast-feeding is not recommended due to potential risk to the nursing infant.
Fire Fighting MeasuresBack to Contents
【Fire Fighting】

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
【Fire Potential】

This material is probably combustible.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Vacuum or sweep up material and place into a suitable disposal container.
Stability and ReactivityBack to Contents
【Stability】

No data.
【Incompatibilities】

Oxidizing agents.
【Decomposition】

Carbon monoxide, carbon dioxide.
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