ChemicalBook >>Sinomenine>>(9alpha,13alpha,14alpha)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one(115-53-7)

(9alpha,13alpha,14alpha)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one(115-53-7)

(9alpha,13alpha,14alpha)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one(115-53-7)
Product IdentificationBack to Contents
【Product Name】

(9alpha,13alpha,14alpha)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one
【Synonyms】

(9a,13a,14a)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one
Cucoline
【CAS】

115-53-7
【Formula】

C19H23NO4
【Molecular Weight】

329.4
【EINECS】

204-094-6
【RTECS】

QD2170000
【RTECS Class】

Drug
【Merck】

12,8692
【Beilstein/Gmelin】

95280
【Beilstein Reference】

5-21-13-00516
Physical and Chemical PropertiesBack to Contents
【Appearance】

A toxic crystalline alkaloid from the root of Sinomenium acutum, structurally related to thebaine.
【Solubility in water】

Insoluble
【Melting Point】

219 - 221
【Boiling Point】

513
【Vapor Pressure】

3E-11 (25 C)
【pKa/pKb】

9.71 (pKa)
【Heat Of Vaporization】

81.5 kJ/mol
【Usage】

Anti-inflammatory.
【Refractive Index】

 
First Aid MeasuresBack to Contents
【Ingestion】

If swallowed, wash out mouth with water provided person is conscious. Call a physician.
【Inhalation】

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.
【Skin】

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
【Eyes】

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.
Handling and StorageBack to Contents
【Storage】

Keep tightly closed. Store in a cool dry place.
Hazards IdentificationBack to Contents
【Inhalation】

Material is irritating to mucous membranes and upper respiratory tract.
【Hazards】

Emits toxic fumes under fire conditions.
【EC Risk Phrase】

45 46 23/24/25 36/37/38
【EC Safety Phrase】

53 22 26 36/37/39 45
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Compatible chemical-resistant gloves. Chemical safety goggles.
【Respirators】

Government approved respirator.
【Exposure Effects】

May cause cancer. May cause heritable genetic damage. Toxic by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. Target organ(s): Liver. Kidneys.
Fire Fighting MeasuresBack to Contents
【Flash Point】

264
【Fire Fighting】

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability and ReactivityBack to Contents
【Incompatibilities】

Strong oxidizing agents.
【Decomposition】

Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas, Phosgene gas.
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