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Tobramycin(32986-56-4)

Tobramycin(32986-56-4)
Product IdentificationBack to Contents
【Product Name】

Tobramycin
【Synonyms】

(2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxy-oxan-2-yl]oxy-2-hydroxy-cyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol
1-Epitobramycin
3'-Deoxykanamycin B
Deoxykanamycin B
Distobram
O-[3-Amino-3-deoxy-a-D-glucopyranosyl-(1[R]6)]-O-[2,6-diamino-2,3,6-trideoxy-a-D-ribohexopyranosyl-(1[R]4)]-2-deoxy-D-streptamine
【CAS】

32986-56-4
【Formula】

C18H37N5O9
【Molecular Weight】

467.52
【EINECS】

251-322-5
【RTECS】

WK2100000
【RTECS Class】

Drug; Mutagen; Reproductive Effector; Human Data; Natural Product
【Merck】

12,9628
【Beilstein/Gmelin】

1357507
【Beilstein Reference】

6-18
Physical and Chemical PropertiesBack to Contents
【Appearance】

white solid
【Solubility in water】

Very soluble
【Melting Point】

168 - 178
【Vapor Pressure】

9E-28 (25 C)
【pKa/pKb】

13.07 (pKa)
【Heat Of Vaporization】

128.7 kJ/mol
【Usage】

Irreversible inhibition of bacterial protein synthesis. Spectrum of activity: gram negative bacteria. Not effective against enterococci. .
First Aid MeasuresBack to Contents
【Ingestion】

If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.
【Inhalation】

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
【Skin】

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
【Eyes】

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.
Handling and StorageBack to Contents
【Storage】

Keep tightly closed. Store at -20 C
Hazards IdentificationBack to Contents
【Inhalation】

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.
【Skin】

May cause skin irritation. May be harmful if absorbed through the skin.
【Eyes】

May cause eye irritation.
【Ingestion】

Toxic if swallowed.
【Hazards】

Emits toxic fumes under fire conditions.
【UN (DOT)】

1544
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Compatible chemical-resistant gloves.
【Respirators】

Government approved respirator.
【Exposure Effects】

Properties of this material have not yet been prepared. Any recommendations are of a general nature. Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested. ALWAYS contact your local poision control authority or medical professional for assistance.
Fire Fighting MeasuresBack to Contents
【Flash Point】

423
【Fire Fighting】

Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
【Fire Potential】

Non-Combustible
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability and ReactivityBack to Contents
【Stability】

Stable at normal temperatures and pressures.
【Incompatibilities】

Strong oxidizing agents.
【Decomposition】

Carbon monoxide, Carbon dioxide, Nitrogen oxides.
【Combustion Products】

Fire may produce irritating, corrosive and/or toxic gases.
Transport InformationBack to Contents
【UN Number】

1544
【Hazard Class】

6.1
【Packing Group】

II
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