ChemicalBook >>Rifampicin>>3-[[(4-methyl-1-piperazinyl)imino]methyl]-rifamycin(13292-46-1)

3-[[(4-methyl-1-piperazinyl)imino]methyl]-rifamycin(13292-46-1)

3-[[(4-methyl-1-piperazinyl)imino]methyl]-rifamycin(13292-46-1)
Product IdentificationBack to Contents
【Product Name】

3-[[(4-methyl-1-piperazinyl)imino]methyl]-rifamycin
【Synonyms】

2,7-(Epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione, 5,6,9,17,19,21-hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-, 21-acetate
3-((4-methyl-1-piperazinyl)iminomethyl)rifamycin sv
8-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin sv
8-(4-Methylpiperazinyliminomethyl) rifamycin sv
Rifadin
Rifamycin, 3-[[(4-methyl-1-piperazinyl)imino]methyl]-
【CAS】

13292-46-1
【Formula】

C43H58N4O12
【Molecular Weight】

822.95
【EINECS】

236-312-0
【RTECS】

VJ7000000
【RTECS Class】

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data
【Merck】

12,8382
【Beilstein/Gmelin】

605085
【EC Class】

harmful
Physical and Chemical PropertiesBack to Contents
【Appearance】

Red to orange platelets from acetone. Odorless.
【Solubility in water】

slightly soluble
【Melting Point】

183 - 188
【pKa/pKb】

1.7, 7.9(at 25℃) (pKa)
【Usage】

Medication.
First Aid MeasuresBack to Contents
【Ingestion】

Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
【Inhalation】

Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
【Skin】

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
【Eyes】

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Handling and StorageBack to Contents
【Storage】

Store in a cool, dry place. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Store protected from light.
【Handling】

Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Store protected from light.
Hazards IdentificationBack to Contents
【Inhalation】

May cause respiratory tract irritation. May cause liver and kidney damage. May cause cardiac abnormalities.
【Skin】

May cause skin irritation. May cause dermatitis.
【Eyes】

May cause eye irritation.
【Ingestion】

May cause irritation of the digestive tract. May cause liver and kidney damage. Human fatalities have been reported from acute poisoning. May be harmful if swallowed.
【EC Risk Phrase】

R 22
【EC Safety Phrase】

S 24
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
【Exposure Effects】

Animal studies have reported that fetal effects/abnormalities may occur when maternal toxicity is seen. Chronic exposure may cause liver damage. Chronic exposure may cause kidney damage. Animal studies have reported the development of tumors. Cancer suspect agent.
Fire Fighting MeasuresBack to Contents
【Fire Fighting】

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation.
Stability and ReactivityBack to Contents
【Incompatibilities】

Oxidizing agents.
【Stability】

Stable under normal shipping and handling conditions.
【Decomposition】

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Transport InformationBack to Contents
【HS Code】

2941 90 00
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