ChemicalBook >>Clozapine>>8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine(5786-21-0)

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine(5786-21-0)

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine(5786-21-0)
Product IdentificationBack to Contents
【Product Name】

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
【Synonyms】

8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
Azaleptine
Clorazil
Clozaril
Iprox
Leponex
【CAS】

5786-21-0
【Formula】

C18H19ClN4
【Molecular Weight】

326.83
【EINECS】

227-313-7
【RTECS】

HP1750000
【RTECS Class】

Drug; Mutagen; Reproductive Effector; Human Data
【Merck】

12,2484
【Beilstein/Gmelin】

764984
【Beilstein Reference】

5-25-11-00364
Physical and Chemical PropertiesBack to Contents
【Appearance】

Yellow crystals from acetone-petroleum ether.
【Solubility in water】

Insoluble
【Melting Point】

182
【Boiling Point】

489
【Vapor Pressure】

1E-9 (25 C)
【pKa/pKb】

7.67 (pKb)
【Heat Of Vaporization】

75.5 kJ/mol
【Usage】

Atypical antipsychotic compound. Selective antagonist for d4-dopamine receptor. Antagonist at 5-ht2a, 5-ht2c, 5-ht3, 5-ht6, and 5-ht7serotonin receptors.
First Aid MeasuresBack to Contents
【Ingestion】

If swallowed, wash out mouth with water provided person is conscious. Call a physician.
【Inhalation】

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
【Skin】

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.
【Eyes】

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.
Handling and StorageBack to Contents
【Storage】

Keep tightly closed.
Hazards IdentificationBack to Contents
【Inhalation】

Material is irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.
【Skin】

Causes skin irritation. May be harmful if absorbed through the skin.
【Eyes】

Causes eye irritation.
【Ingestion】

Harmful if swallowed.
【Hazards】

Emits toxic fumes under fire conditions.
【EC Risk Phrase】

22 36/37/38
【EC Safety Phrase】

26
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Compatible chemical-resistant gloves. Chemical safety goggles.
【Respirators】

Government approved respirator.
【Exposure Effects】

Properties of this material have not yet been prepared. Any recommendations are of a general nature. Many chemicals cause irritation of the eyes, skin, and respiratory tract. In severe cases respiratory tract irritation can progress to ARDS/acute lung injury which may be delayed in onset for up to 24 to 72 hours in some cases Irritation or burns of the esophagus or gastrointestinal tract are also possible if caustic or irritant chemicals are ingested. ALWAYS contact your local poision control authority or medical professional for assistance.
Fire Fighting MeasuresBack to Contents
【Flash Point】

250
【Fire Fighting】

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Stability and ReactivityBack to Contents
【Incompatibilities】

Oxidizing agents.
【Stability】

Stable at normal temperatures and pressures.
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