ChemicalBook >>Aristolochic acid>>8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid(313-67-7)

8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid(313-67-7)

8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid(313-67-7)
Product IdentificationBack to Contents
【Product Name】

8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid
【Synonyms】

Aristolochic acid 1
Aristolochic acid A
Aristolochic acid I
Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro-
Tardolyt
TR 1736
【CAS】

313-67-7
【Formula】

C17H11NO7
【Molecular Weight】

341.27
【EINECS】

206-238-3
【RTECS】

CF3325000
【RTECS Class】

Tumorigen; Drug; Mutagen; Human Data; Natural Product
【Merck】

12,822
【Beilstein/Gmelin】

345159
【Beilstein Reference】

5-19-07-00611
Physical and Chemical PropertiesBack to Contents
【Appearance】

Orange-yellow powder.
【Solubility in water】

Slightly soluble
【Density】

1.499 g/cm3
【pKa/pKb】

3.18 (pKa)
【Partition Coefficient】

2.79
【Usage】

Contained in a number of botanical products sold as traditional medicines or as dietary supplements or weight-loss remedies. It’s use can cause permanent kidney damage and cancer.
First Aid MeasuresBack to Contents
【Ingestion】

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
【Inhalation】

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
【Skin】

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
【Eyes】

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Handling and StorageBack to Contents
【Storage】

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Poison room locked.
【Handling】

Wash thoroughly after handling. Wash hands before eating. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Hazards IdentificationBack to Contents
【Inhalation】

May cause respiratory tract irritation.
【Skin】

May cause skin irritation. Prolonged and/or repeated contact may cause irritation and/or dermatitis.
【Eyes】

May cause eye irritation.
【Ingestion】

Harmful if swallowed. May cause irritation of the digestive tract. May cause kidney damage. Human fatalities have been reported from acute poisoning.
【UN (DOT)】

1544
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
【Exposure Effects】

Prolonged or repeated skin contact may cause dermatitis. May cause kidney damage.
【Poison Class】

2
Fire Fighting MeasuresBack to Contents
【Fire Fighting】

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
【Fire Potential】

Non-Combustible
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.
Stability and ReactivityBack to Contents
【Incompatibilities】

Oxidizing agents.
【Stability】

Stable at room temperature in closed containers under normal storage and handling conditions.
【Decomposition】

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
【Combustion Products】

Fire may produce irritating, corrosive and/or toxic gases.
Transport InformationBack to Contents
【UN Number】

1544
【Hazard Class】

6.1
【Packing Group】

I; II; III
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