Oxyresveratrol是能够抑制脑缺血中的凋亡细胞的死亡，它能够有效清除H2O2和 NO
中文名称
Oxyresveratrol.
中文别名
氧化白藜芦醇;4-[(E)-2-(3,5-二羟基苯基)乙烯基]苯-1,3-二醇;氧化白黎芦醇;Oxyresveratrol 氧化白藜芦醇;经氧化白藜芦醇;氧化白藜芦醇 标准品;氧化白藜芦醇1;氧化白藜芦醇对照品;找氧化白藜芦醇;2,4,3',5'-四羟基二苯乙烯;2,4,3',5'-四羟基茋;2,3',4,5'-四羟基-反-二苯乙烯
英文名称
Oxyresveratrol
英文别名
Oxyresveratrol;4-[(E)-2-(3,5-Dihydroxyphenyl)ethenyl]benzene-1,3-diol;(E)-4-(3,5-Dihydroxystyryl)benzene-1,3-diol;trans-Oxyresveratrol;2,3',4,5'-Tetrahydroxy-trans-stilbene;2,4,3',5'-Tetrahydroxystilbene;3,4,3',5'-tetrahydroxy-trans-stilbene;OXYLRESVERATROL;Puag-haad;trans-2,3',4,5'-tetrahydroxystilbene;(E)-2,3′,4,5′-Stilbenetetrol;2,3′,4,5′-Tetrahydroxy-trans-stilbene;4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol;[ "" ];4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol;Hydroxyresveratrol;Tetrahydroxystilbene;6V071CP5CR;1,3-Benzenediol, 4-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-;2,3',4,5'-Tetrahydroxystilbene;Oxyresveratrol A;AK158555;4-(3,5-Dihydroxystyryl
Cas No.
29700-22-9
分子式
C14H12O4
分子量
244.24
生物活性
Oxyresveratrol (trans-Oxyresveratrol) is a potent naturally occurring antioxidant and free radical scavenger (IC50 of 28.9 μM against DPPH free radicals). Oxyresveratrol is potent and noncompetitive tyrosinase inhibitor with an IC50 value of 1.2 μM for mushroom tyrosinase. Oxyresveratrol is effective against HSV-1, HSV-2 and varicella-zoster virus, and has neuroprotective effects.
性状
Solid
IC50 & Target[1][2]
HSV-1
HSV-2
体外研究(In Vitro)
Cultures of the murine microglial cell line N9 and primary mixed glial cultures were used to test the drug effects of NO production upon expression of the inducible isoform of nitric oxide synthase (iNOS). Oxyresveratrol considerably diminished NO (nitrite) levels (IC50 of 45.31 μM) in murine microglial cells.
Oxyresveratrol can inhibit DOPA oxidase activity, cyclooxygenase, and rat liver mitochondrial ATPase activity.
Oxyresveratrol exhibits 63.3% inhibition at 100 μM and an IC50 value of 52.7 μM on the murine tyrosinase activity. Oxyresveratrol exhibits a dose-dependent inhibitory effect on L-tyrosine oxidation by the murine tyrosinase but does not inhibit the promoter activity of the enzyme gene. Oxyresveratrol exhibits significant inhibitory effects at 10 μM and higher concentrations on murine tyrosinase activity.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Oxyresveratrol (2-30 mg/kg; intraperitoneal injection; twice) treatment reduces the brain infarct volume in MCAO rats. Oxyresveratrol treatment diminishes cytochrome c release and decreased caspase-3 activation, and reduces the number of apoptotic nuclei in ischemic brain in MCAO rats.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: Adult male Wistar rats (300-350 g) with middle cerebral artery occlusion (MCAO)
Dosage: 2 mg/kg, 10 mg/kg, 20 mg/kg and 30 mg/kg
Administration: Intraperitoneal injection; twice (at the time of occlusion and at the time of reperfusion)
Result: Reduced the brain infarct volume in MCAO rats.
运输条件
Room temperature or refrigerated transportation.
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