基本信息：
EB病毒（Epstein Barr Virus，EBV）是第一个被发现的人类肿瘤病毒（1964年），是一种嗜淋巴性人疱疹病毒，主要侵染B淋巴细胞。CD21是EB病毒的受体，这种受体可能和B淋巴细胞的补体受体相同或密切相关。人是EB病毒感染的宿主，主要通过唾液传播，如接吻，共同用餐。所以EB病毒感染也被称之为热吻病。常见可导致疾病有传染性单核细胞增多症，此外EB病毒与鼻咽癌、伯基特淋巴瘤的发生有密切相关性，被列为可能致癌的人类肿瘤病毒之一。
具体分类：
·EB病毒分型较多，目前国际常用分型以EBNA2基因表达不同为依据，分为A、B两型。
·A型在全球最常见，尤其是亚洲地区，B型在非洲地区更为常见，另外有LMP1缺失型、LMP1 XhoI等分型。
·在不同的感染状态下，EB病毒表达的抗原也不同，包括增殖性感染表达的抗原和潜伏感染期表达的抗原，前者又可分为EB病毒早期抗原、EB病毒晚期抗原，后者可分为EB病毒核抗原、潜伏膜蛋白。
需要完善的检查:
·EB病毒血浆和PBMC定量检查
·EB病毒感染淋巴细胞亚群定量检查
·PET/CT + 淋巴结EBER病理检查
目前对抗EB病毒方法主要有：
·核苷模拟物（阿西克洛韦、瓦莱西克洛韦、甘西克洛韦和瓦尔甘奇洛韦)
·核苷酸模拟
·焦磷酸盐模拟
·EBV蛋白激酶BGLF4的抑制剂
·EBV DNA聚合酶抑制剂
·EBV核抗原1(EBNA1）的抑制剂
·VST/CTL/CAR-T细胞疗法
产品链接：https://www.antibodysystem.com/index/search?wd=EBV
名称：EB病毒（Epstein Barr Virus，EBV）相关重组蛋白和抗体
相关产品：
Anti-EBV/HHV-4 LMP1/BNLF1 Antibody (A4) (RVV07008)
InVivoMAb Anti-EBV/HHV4 gB/BALF4 Antibody (Iv0133)(Iv0134) (VVV22001)
Anti-EBV/HHV-4 gH/BXLF2 Antibody (CL40) (CL59) (RVV15101)
Anti-EBV/HHV-4 gH/gL Complexes Antibody (769B10) (AMMO1) (RVV15103)
Anti-EBV/HHV-4 BLLF1/MA Antibody (72A1) (RVV15201)
Anti-EBV/HHV-4 EBNA1/BKRF1 Antibody (3D4) (RVV15301)
Anti-EBV/HHV-4 gL/BKRF2 Antibody (E1D1) (RVV15401)
Recombinant EBV/HHV4 BLLF1/MA/GP350 Protein, C-His (EVV15201)
Recombinant EBV/HHV4 gH & gL & gp42 Trimer, C-Strep & C-His & C-His (EVV15101)
Recombinant EBV/HHV4 gH & gL Complex, C-Strep & C-His (EVV15102)
Recombinant EBV/HHV4 gH & gp42 Complex, C-Strep & C-His (EVV15103)
Recombinant EBV/HHV4 GP42/Glycoprotein 42 Protein, C-His (EVV25101)
Recombinant EBV/HHV-4 gH/BXLF2 Protein, C-Strep (EVV15104)
Recombinant EBV/HHV-4 gB/BALF4 Protein, C-His (EVV22001)
Recombinant EBV/HHV4 EBNA1/BKRF1 Protein, N-His (YVV15301)
Anti-EBV/HHV4 gB/BALF4 Antibody (1D8) (CL55)(AMMO5) (RVV22001)
Anti-EBV/HHV-4 GP42/Glycoprotein 42 Antibody (SAA2098) (RVV25101)
Anti-EBV/HHV-4 LMP1/BNLF1 Antibody (B2A4) (B8)(G5)(F5)(E2)(H3) (RVV07005)
Anti-EBV/HHV-4 EBNA1/BKRF1 Antibody (16D2) (RVV15302)
Anti-EBV/HHV-4 LMP1/BNLF1 Antibody (A3H5)(B10E7) (H11F6) (B10B7)(RVV07002) (RVV07001)
用途范围：仅用于科研
储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
产品购买联系方式：027-65279366 /18162686757
邮箱：biolab-reagents@atagenix.com
QQ：2663991332
参考文献：
Molecular mechanisms of EBV-driven cell cycle progression and oncogenesis. PMID: 30386928
EBV-Encoded Latent Genes. PMID: 29896676
Methionine metabolism controls the B cell EBV epigenome and viral latency. PMID: 36070681
EBV Noncoding RNAs. PMID: 26428375
Epstein-Barr virus: Biology and clinical disease. PMID: 36113467
EBV and Apoptosis: The Viral Master Regulator of Cell Fate? PMID: 29137176
Epstein-Barr virus strain variation and cancer. PMID: 30697862
Encyclopedia of EBV-Encoded Lytic Genes: An Update. PMID: 29896677
EBV Persistence--Introducing the Virus. PMID: 26424647
EBV Infection of Mice with Reconstituted Human Immune System Components. PMID: 26428383
EBV's open sesame. PMID: 1323889
Epstein-Barr Virus. PMID: 27337443
Conquering the Nuclear Envelope Barriers by EBV Lytic Replication. PMID: 33919628
Role of epigenetics in EBV regulation and pathogenesis. PMID: 25046522
Primary Immunodeficiencies Associated with EBV Disease. PMID: 26424649
Tumor Associations of EBV--Historical Perspectives. PMID: 26424641
An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma. PMID: 31186275
[Lifecycles of EBV and cancer]. PMID: 25765985
The pathogenesis of Epstein-Barr virus persistent infection. PMID: 23683686
New strategies and patent therapeutics in EBV-associated diseases. PMID: 21034415
EBV-associated diseases in the AIDS patient. PMID: 17672041
Progress and problems in understanding and managing primary Epstein-Barr virus infections. PMID: 21233512
Distinctive EBV infection characteristics in children from a developing country. PMID: 32004689
The switch between EBV latency and replication. PMID: 2549738
Epstein-Barr virus-encoded EBNA1 and ZEBRA: targets for therapeutic strategies against EBV-carrying cancers. PMID: 25186125
Restricted expression of EBV encoded proteins in in vitro infected CLL cells. PMID: 21034831
Measuring Epstein-Barr virus (EBV) load: the significance and application for each EBV-associated disease. PMID: 18494041
Role of epithelium in EBV persistence and pathogenesis of B-cell tumours. PMID: 2895366
Interplay among viral antigens, cellular pathways and tumor microenvironment in the pathogenesis of EBV-driven lymphomas. PMID: 23917255
Adoptive T-Cell Immunotherapy. PMID: 26428384
Interferon regulatory factor 7: a key cellular mediator of LMP-1 in EBV latency and transformation. PMID: 11669606