文章标题：Effects of di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-ovarian axis in adult female rats
期刊：REPRODUCTIVE TOXICOLOGY
作者列表：Te Liu, Na Li, Jian Zhu, Guangyan Yu, Kun Guo, Liting Zhou, Dongchun Zheng, Xiaofeng Qu, Jian Huang, Xin Chen, Shuyue Wang, Lin Ye
发表时间：2014-3-24
影响因子：2.771
DOI:10.1016/j.reprotox.2014.03.006
主要研究成果：Abstract
Di-(2-ethylhexyl) phthalate (DEHP), an environmental endocrine disruptor, is widely present in the environment and some products with phthalate plasticizer. It has become a serious problem in recent years. The effect of DEHP on female reproductive system is still not well-studied. This study was to investigate the effects of DEHP on hypothalamus-pituitary-ovarian axis in adult female rats. Compared with control rats, the DEHP-treated rats showed: (1) lower body weight; (2) lower organ coefficient of ovary; (3) higher GnRH level in the hypothalamus; (4) higher mRNA and protein levels of GnRHR in the pituitary; and (5) lower serum sex hormone levels. Our data reveal that DEHP exposure may lead to the disruption of estrogen biosynthesis pathways in female rats and imbalance of hypothalamus-pituitary-ovarian axis. DEHP may impose negative influence on the development and function of the reproductive system in female rats.