文章标题：Preventing effect on diet-induced obesity of water-extract from masson pine pollen on mice
作者列表：Y Geng, H Zhang, H Song, L Zhang, J Xu, M Liu, S Chen, L Han
期刊：African Journal of Traditional Complementary and Alternative Medicines
发表时间：2015-9-17
影响因子：0.5
DOI:10.4314/ajtcam.v12i5.3
主要研究成果：Abstract
Background: This study was carried out in order to investigate the preventing effect of water-extract from masson pine pollen (PWE) on obesity in mice.
Materials and Methods: Sixty male KM mice (bodyweight was 19±1g) were divided randomly into six groups: normal control group (NC), high fat group (FC), positive control group (Orlistat, 0.05g/kg bw·d, PC), low-dose PWE group (0.0625g/kg bw·d, PWEL), medium-dose group (0.125g/kg bw·d, PWEM) and high-dose group (0.25g/kg bw·d, PWEH). Mice were treated by intragastric administration daily for 6 weeks.
Results: The body weight changes of three PWE groups decreased obviously. In serum, TC of PWEH group reduced remarkably (P<0.05); TG of three PWE groups had significantly declined (P<0.01); HDLC of PWEM and PWEH groups had significantly increased (P<0.05). Leptin level of PWEM and PWEH groups had significantly increased (P<0.01). Adiponectin, resistin level and the activity of CPT-I of PWE groups increased remarkably (P<0.01). Orexigenic peptides NPY and AgRP in serum of PWE groups had significantly declined (P<0.01). Anorexigenic peptides POMC had no difference with each other, and CART had declined.
Conclusion: PWE could not only promote the absorption and synthesis of fat but also promote the oxidation of fat. Critical was that the oxidation was stronger than the synthesis.
Conclusion: α-MMC inhibits cancer cell growth and proliferation, and facilitates their apoptosis by positively regulating the ratio of Bax/Bcl2. The anti-liver cancer effect of α-MMC is mediated via HMGB1-RAGE and AKT signaling pathways