文章标题：Mechanism of platelet-rich plasma inhibiting inflammatory response, oxidative stress, and senescence in synovial fibroblasts of patients with knee osteoarthritis via UBE2C based on transcriptome sequencing analysis
作者列表：Zou Lili, Ma Yujuan, Hu Mingxian, Sun Zhenshuang, Shi Zhijun, Gao Jiahuan, Cai Xiguo
影响因子：3
期刊：JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
发表时间：2026-3-26
DOI:10.1007/s10863-026-10105-1
文献主题：Abstract
Background
The incidence of knee osteoarthritis (KOA) continues to rise with the aging of the population, which seriously reduces the quality of life of patients. Platelet-rich plasma (PRP), a biological agent rich in growth factors and cytokines, has shown promising potential in the treatment of KOA in recent years. However, the specific molecular mechanism of its regulation of the pathological process is not clear.
Methods
Based on the GSE157364 dataset, DESeq2 software was used to analyze the differentially expressed genes (DEGs) of OA-FLSs between the PRP group and the Ctrl group. KEGG pathway and GO function enrichment analysis were performed by SangerBox. The genes related to cell senescence, inflammatory response and oxidative stress were screened from the GeneCards database, and the intersection was obtained by a Venn diagram.
Results