产品属性:
产品名称 | 规格 | CAS号 | 型号 |
(-)-epigallocatechin | 1mg 5mg 10mg 20mg | 970-74-1 | EY-Y0163798 |
Cas No.970-74-1
别名
化学名 (2R,3R)-2-(3,4,5-trihydroxyphenyl)chroman-3,5,7-triol
分子式 C15H14O7
分子量 306.27
溶解度 DMF: 25 mg/ml,DMSO: 15 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述:
(-)-epigallocatechin is a polyphenol in green tea [1].
(-)-epigallocatechin (EGC) plays an important role in cell growth inhibition, apoptosis and bone metabolism.
(-)-epigallocatechin is a polyphenol in green tea. In MCF-7 and MDA-MB-231 breast cancer cell lines, EGC significantly inhibited cell growth and induced apoptosis, which were independent of p53 and required Fas signaling [1]. In H1299 cells, EGC (10-40 μM) reduced cell viability in a dose dependent way. In Hep-3B cells, EGC (40/80 μM) also reduced cell viability. However, EGC (20 μM) slightly increased cell viabilities in SK-Hep-1 and OECM-1 cells but significantly decreased cell viabilities at concentrations up to 40 μM. EGC exhibited cytotoxicity with IC50 values of 26, 33 and 22 μM in H1299, OECM-1 and SAS cells, respectively. In H1299, OECM-1 and SAS cells, EGC (40 μM) induced apoptosis by 30, 28 and 24%, respectively. In H1299 cells, EGC (40 μM) inhibited hTERT promoter activity in a time- and dose- dependent way and also inhibited hTERT mRNA expression, which was important for cell proliferation [2].
In ICR mice, EGC (0.5 and 1.0 g/kg/d) significantly inhibited platelet aggregation by 18.4% and 25.6% respectively and also significantly prolonged blood clotting time (BCT) and bleeding time (BT), which suggested that the blood anticoagulation and antiplatelet activity of EGC [3].
关键字: 970-74-1;C15H14O7;(-)-epigallocatechin;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业,公司自成立以来,秉承""全心全意服务于科研工作者""的企业理念,立足生物科技领域,运用生物技术和科研试剂,发展现代生物科技,为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品,服务生物科技领域的科学研究人员。
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