产品属性：
产品名称 | 规格 | CAS号 | 型号 |
Isatin | 100mg 500mg | 91-56-5 | EY-Y0165674 |
Cas No.91-56-5
别名
化学名 indoline-2,3-dione
分子式 C8H5NO2
分子量 147.13
溶解度 Soluble in DMSO
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
IC50: 15 μM
Isatin is a monoamine oxidase inhibitor.
Monoamine oxidase inhibitors have been used as therapies for the treatment of depression, particularly in treating atypical depression. Monoamine oxidase inhibitors are also used in the treatment of Parkinson's disease and other disorders.
In vitro: Previous study found that isatin treatment at 1-400 μM for 24h could induce a significant dose-dependent increase in MTT metabolism by SH-SY5Y cells, which was not due to the increase in cell division. In addition, isatin at the higher concentrations was able to trigger cell death, though MTT metabolism was still increased, indicating that the surviving cells were hypermetabolic. With a longer treatment, isatin was found to cause cell death in a dose-dependent manner, and the predominant mode of cell death was apoptosis at lower concentrations, while at the highest concentration increasing numbers of necrotic cells were also observed [1].
In vivo: Animal study showed that the motor activity of Japanese encephalitis virus (JEV)-induced rats receiving isatin was improved significantly when compared with that of untreated JEV-infected rats. In addition, isatin was able to prevent the decrease in striatal DA levels in JEV-rats and the increased turnover of dopamine (DA) (DOPAC/DA) induced by JEV was significantly inhibited by isatin. Such results indicated that the exogenously administered isatin was able to improve JEV-induced parkinsonism via increasing the striatum DA concentrations [2].
Clinical trial: Up to now, isatin is still in the preclinical development stage.
关键字： 91-56-5;C8H5NO2;Isatin;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业，公司自成立以来，秉承""全心全意服务于科研工作者""的企业理念，立足生物科技领域，运用生物技术和科研试剂，发展现代生物科技，为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品，服务生物科技领域的科学研究人员。
公司具有对普通货物、冷藏及冷冻仓库的存储、包装及运输能力。
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