Product Name：Echistatin,α1 isoform
CAS No.：154303-05-6
Synonyms：整合素拮抗剂多肽Echistatin,α1 isoform
Catalog No.：218P047
Brand：HongTide（上海鸿肽生物）
Description：Echistatin, α1 isoform是一种有效的不可逆αVβ3整合素拮抗剂 (Ki = 0.27 nM)多肽，序列中含有49个氨基酸，并且含有4对二硫键。Echistatin, α1 isoform能起到破坏破骨细胞与骨骼的附着并抑制骨骼重吸收 (IC50 = 0.1 nM)的作用，并能通过体外抑制糖蛋白IIb/IIIa (GpIIb/IIIa, αIIbβ3) 受体(IC50 = 30 nM) 防止ADP诱导的血小板聚集。
Echistatin, α Isoform is an effective irreversible method α V β An integrin antagonist (Ki=0.27 nM) peptide that contains 49 amino acids in its sequence and contains four pairs of disulfide bonds. Echistatin, α Isoform can disrupt the attachment of osteoclasts to bone and inhibit bone resorption (IC50=0.1 nM), and can inhibit glycoprotein IIb/IIIa (GpIIb/IIIa, α IIb β 3) Receptors (IC50=30 nM) prevent ADP-induced platelet aggregation.
Purity (HPLC) ≥95.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | ECESGPCCRNCKFLKEGTICKRARGDDMDDYCNGKTCDCPRNPHKGPAT (Disulfide bridge：Cys2-Cys11;Cys7-Cys32;Cys8-Cys37;Cys20-Cys39) |
Sequence(3-letter code) | H-Glu-Cys-Glu-Ser-Gly-Pro-Cys-Cys-Arg-Asn-Cys-Lys-Phe-Leu-Lys-Glu-Gly-Thr-Ile-Cys-Lys-Arg-Ala-Arg- Gly-Asp-Asp-Met-Asp-Asp-Tyr-Cys-Asn-Gly-Lys-Thr-Cys-Asp-Cys-Pro-Arg-Asn-Pro-His-Lys-Gly-Pro-Ala-Thr-OH (Disulfide bridge：Cys2-Cys11;Cys7-Cys32;Cys8-Cys37;Cys20-Cys39) |
Peptide Structure | 
|
Molecular Formula | C217H341N71O74S9 |
Molecular Weight | 5417.07 |
订购联系方式：
上海鸿肽生物科技有限公司
手机： +86-18018095145 （同微信号）
QQ: 3259098395
邮箱：sales1@hongtide.com
关键字： Echistatin,α1 isofor;154303-05-6;整合素拮抗剂多肽;多肽;多肽合成;
上海鸿肽生物科技有限公司（简称：鸿肽生物）是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖：定制多肽、目录多肽、氨基酸衍生物、小分子化合物；公司自成立以来，秉持“用质量作船， 以服务为帆，为科研服务”的企业理念，为国内外众多科研工作者提供了优质的服务及产品。