Host:Rabbit
Target Protein:phospho-MLKL (Ser345)
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:74568
Swiss Prot:Q9D2Y4
Source:KLH conjugated Synthesised phosphopeptide derived from mouse MLKL around the phosphorylation site of Ser345 :
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015].
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-1000)
IHC-P(1:50-100)
IHC-F(1:50-100)
Cross Reactive Species:Mouse
本产品仅供科研使用。不能用于人和动物治疗等其它临床诊断使用！
关键字： phospho-MLKL;p-MLKL(S345);hMLKL;MLKL_HUMAN;MLKL(p-S345);
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