抗体

抗体是存在于体液和淋巴细胞表面上的能与抗原特异性结合的免疫球蛋白。抗体是由B细胞分化成的浆细胞产生的。抗体分子具有结合部位(结合簇),能与相对应的抗原决定簇结合。由于不同的抗原与抗体特异性结合表现出各种不同的反应,因而抗体有各种不同的名称,如凝集素、沉淀素、抗毒素、溶血素、溶菌素、补体结合抗体等。这些结合,在适当的条件下,可发生直接或间接的可见反应,可作为临床诊断的一种方法。抗体有作用于相对应的细胞、组织、毒素和酶等一系列的生物学活性,与对应抗原在机体内结合后,可以被吞噬、排泄而将抗原清除,或使抗原失去致病作用,故常用以防治某些疾病。这在医学应用中,曾发挥了巨大的作用。在另一些情况下,抗体与抗原结合形成的免疫复合物,能损伤组织、细胞,引起超敏反应或免疫性疾病等不良后果。抗体过去统称为丙种(γ)球蛋白(γG,GG),这是因早年用电泳法分析血清时看到抗体活性在γ部分而命名的。后来证明,抗体并不都在γ区; 反之,位于γ区的球蛋白也不一定都具有抗体活性。1964年世界卫生组织专门会议将具有抗体活性以及与抗体相关的球蛋白统称为免疫球蛋白(Ig)。目前多数学者认为抗体这一名词只表明它的生物学活性,如在靶抗原已被确定的场合。可与靶抗原特异性结合,但不能表明它的化学本质。而免疫球蛋白一词既意味着有免疫活性,更着重表示它的化学含义,是指单一的分子。不严格区分时,二词可以混用。B淋巴细胞受抗原刺激后,怎样变成能够分泌抗体的浆细胞或转变成记忆细胞,这些机制还远未搞清。


抗体的产生有一定的规律。当抗原第一次进入机体时经过一段潜伏期,抗体效价逐步上升,达到高峰后,维持一短暂的时期,以后又逐渐下降,此为初次应答或初次抗体应答。但在第二次再接触同样抗原后,开始时表现为原有抗体量的略为降低。这是因为原有抗体的一部分与再次注入的抗原结合的缘故。随后抗体效价的上升较初次为快,其高峰时的效价也比初次为高,持续的时间也长,此即所谓二次(抗体)应答或再次(抗体) 应答。由抗原刺激所产生的抗体,经过一段时间后即逐渐消失,以后再接触抗原,可使已消失的抗体迅速上升,是为回忆应答。广义的回忆应答可包括二次应答。若再次刺激的抗原与初次相同,则为特异性回忆应答,若与初次不同,则为非特异性回忆应答。非特异性回忆应答的抗体只是暂时性上升,短时间内即很快下降。
抗体的一般特性包括: ①特异性: 抗体只能与相应抗原发生特异性结合,而不能与其他无关的抗原结合。这是由抗体的结合部位与抗原决定簇的理化性质恰相对应所决定的。②不均一性: 抗体是一组不同种类的免疫球蛋白分子所组成(参见“免疫球蛋白”)。它们的氨基酸组成和排列以及立体构型既相似又略有差别,因而其大小、形状和功能也互有差异。例如天然抗原性物质的表面含有许多不同的决定簇,由其刺激机体产生的抗体,就包含着针对这些不同决定簇的抗体。例如抗伤寒杆菌的抗体,至少应包括抗菌体的O抗体,抗鞭毛的H抗体以及抗毒力 (Vi)抗原的Vi抗体; 事实上针对菌体的抗体,由于菌体抗原(9,12)不同,其相应抗体也互不相同。就是针对某一决定簇的抗体,也包括IgG、IgA、IgM、IgD和IgE五大类及其亚类,虽然在某一个体内不一定同时都有。对某一类抗体(如IgG)来说,不同种系以及不同个体动物间所产生的抗体也都不完全相同。这种不同是由遗传决定的。抗体的这些不均一性,在临床上都是必须注意的问题。③双重性: 抗体一方面可与抗原特异性结合,发挥其免疫功能; 另一方面,由于它本身是高分子蛋白质,当被注入异种动物体内时,就具有抗体和抗原的双重作用。在用异种动物的抗血清反复注射以防治疾病时,必须注意有发生过敏反应的可能性。关于抗体产生的机制,曾有过许多假设和学说。


人类免疫球蛋白已鉴定出5种,它们是:IgG,IgA,IgM,IgD和IgE,差异发在H链上,分别由称为γ、α、μ、δ和ε的H链构成。
IgG是人类血清中的主要免疫球蛋白。抗原激发后产生的主要抗体类型,就是这种单体。胎儿虽不产生IgG,但它能迅速通过胎盘,故胎儿和新生儿血清中皆能检出母体的IgG。根据重链的不同,IgG可分为4个亚类:γ1,γ2,γ3,γ4。有些抗原激起的抗体反应,4亚类可说旗鼓相当,但有些抗原则是以其中某一亚类为主。作用于糖类的抗体常为IgG2;抗DNA抗体主要是IgG1和IgG3。在各种亚类中,IgG3的合成速率最低,而分解速率最高,血清半衰期最短。有关IgG的各种生物学和物理特性,均见表1及表2。
IgA有单体也有二聚体。它是分泌物中的主要免疫球蛋白,并以二聚体存在,后者是以多肽连接链(J链)和二硫桥互连的。此外,分泌物(涎液、泪液、肠液中的二聚体,还含有1条称为分泌成分(SC)或分泌片(secretary piece)的多肽链。SC似能保护二聚体IgA,免于胃肠道蛋白水解酶的消化作用。它是由局部浆液型分泌性上皮细胞产生的,位于这些细胞的表膜,这使人想到:SC可能是二聚体IgA的受体。SC片越过或由这些细胞间通过时,不断增加,据认为,分子之能藉胞泌作用(与胞饮作用相对)通过粘膜上皮,即缘于此。因此,分泌性IgA的生成,就可认为是不寻常的,因为它是两种不同类型细胞(即抗体分泌性浆细胞和浆膜上皮细胞)的协作产物。按其α重链的不同,IgA可分为IgA1和IgA2两亚类。后者又可按其遗传标记(genetic markers)的不同,分为A2m(1)和A2m(2)两亚种。
IgM是最大的免疫球蛋白(分子量890,000),为5个相同亚单位组成的五聚体,各有两条K或λ轻链和两条μ重链。此外,IgM还有1个与二聚体IgA相似的J链,使分子结合更为牢靠。IgM对补体结合至为有效,对红细胞和细菌的凝集作用以及杀菌反应,也比IgG有效得多。单体IgM见于B细胞表面,据信是起抗原受体的作用。初次给予1剂抗原后,经过一段起始延搁,首先出现的抗体就是IgM,一般于7日到达顶峰。但此时IgG抗体亦可检出,一般于10~14日到达最高效价。在IgG效价增长期间,IgM效价开始下降,迨至初次抗原剂量4~5周后,已难以检出。2次反应(回忆反应或增强反应)时,IgM和IgG效价皆呈指数性增长,但IgG反应显然更强,持续也更久;IgM效价则与1次反应时相同,或略有增高。产IgM细胞记忆功能不佳,虽经2次抗原激发,亦无典型回忆反应。故IgM的存在有助于确定是否为新发感染。有证据提示带IgG或IgA淋巴细胞是由带IgM或IgM/IgD淋巴细胞前体发育来的。
IgD是由两条δ重链和两条κ或λ轻链构成的单体。在血清免疫球蛋白中,含量甚微,合成速率大约不到IgD的1/100。IgD的分解速率亦高,血浆半衰期只有3日。IgD不与补体结合,也不对皮肤致敏。大多数脐带和成人的B细胞表面,都有IgD,有人认为IgD可能是一种早期抗原细胞受体。
IgE是由两条ε重链和两条κ或λ轻链构成的大单体。血清含量至微,血浆半衰期最短,合成速率最低,分解速率在各种免疫球蛋白中也是最快的。IgE在即发型超敏反应中起主要作用。它以Fc部分紧密地结合在肥大细胞和碱性细胞的受体上。继而抗原(变应原)与临近二IgE分子相互作用,形成抗原桥。由此引起的局部膜改变,促使介质释出(组胺、慢反应物质、酸性细胞趋化因子),从而触发即发型超敏反应。特应性(atopic)者的变应原特异性IgE水平增高。据认为IgE对寄生虫有保护作用,但尚无确切资料得以证实。


【参考资料】
中国医学百科全书编辑委员会 编;谢少文 主编.中国医学百科全书·二十一 免疫学.上海:上海科学技术出版社.1983.第7-8页.
赵克健 主编.现代药学名词手册.北京:中国医药科技出版社.2004.第273-274页.
王贤才 主译;廖有谋,郭磊甫等 审校.临床药物大典.青岛:青岛出版社.1994.第1415-1419页.

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抗山羊二抗,HRP标记羊抗人IGA-HRP羊抗人C3-HRP人白蛋白-HRP辣根过氧化物酶标记兔抗羊IGG辣根过氧化物酶标记STREPTAVIDIN兔抗HRP-HRP(PAP)兔抗绵羊IGG(H&L)二抗,HRP标记羊抗猪IGG-HRP羊抗小鼠IGG-HRP兔抗FITC-HRP羊抗马IGG-HRP兔抗生物素-HRP兔抗猴IGG-HRP羊抗人IGM-HRP羊抗人IGG-HRP兔抗鸡IGG-HRP羊抗人白蛋白-HRP
Biotin标记二抗
生物素标记羊抗鼠IGG(H+L)山羊抗兔IGG(H&L)二抗,BIOTIN标记生物素高效标记山羊抗兔IGG(H+L)生物素标记山羊抗小鼠IGG(H+L)生物素高效标记山羊抗小鼠IGG(H+L)生物素标记山羊抗兔IGG(H+L)
ALP标记二抗
碱性磷酸酯酶标记STREPTAVIDIN碱性磷酸酯酶标记山羊抗小鼠IGG(H+L)碱性磷酸酯酶标记驴抗山羊IGG(H+L)碱性磷酸酯酶标记山羊抗兔IGG(H+L)
荧光标记二抗
羊抗小鼠IGG-RBITC羊抗兔IGG-RBITC羊抗人IGG-FITC兔抗狗IGG-RBITC异硫氰酸罗丹明荧光素标记牛血清白蛋白FITC标记山羊抗小鼠IGG(H+L)兔抗绵羊IGG(H&L)二抗,FITC标记羊抗猪IGG–FITC羊抗小鼠IGG–FITC羊抗牛IGG-RBITC羊抗马IGG–FITC兔抗豚鼠IGG-RBITC羊抗大鼠IGG-RBITC兔抗生物素-FITC羊抗人IGM-RBITCCY3标记驴抗山羊IGG(H+L)兔抗羊IGG-RBITC羊抗马IGG-RBITC
其他
兔抗猪IGG(免疫血清)兔抗小鼠IGG(免疫血清)兔抗牛IGG-HRP兔抗大鼠IGG(免疫血清)羊抗人IGM(Μ链特异)羊抗兔IGG(免疫血清)羊抗鸡IGG(免疫血清)兔抗AVIDIN(卵清亲合素)(免疫血清)羊抗人纤维蛋白原兔抗人IGM(免疫血清)兔抗狗IGG(免疫血清)羊抗牛IGG(免疫血清)兔抗豚鼠IGG(免疫血清)兔抗鸡IGG(免疫血清)驴抗羊IGG 免疫血清羊抗人白蛋白(免疫血清)兔抗人IGA (免疫血清)兔抗马IGG(免疫血清)
Insulin Signaling
PHOSPHO-SHIP (TYR1020) RABBIT MONOCLONAL ANTIBODYRAB9 RABBIT MONOCLONAL ANTIBODYPHOSPHO-IRS1(SER307)抗体IRS1 RABBIT MONOCLONAL ANTIBODY内皮素-1(抗体)TAK875 (GPR激动剂)PHOSPHO-IRS1(SER302)抗体INSULIN RABBIT MONOCLONAL ANTIBODYANTI-P GLYCOPROTEIN抗体FEBUXOSTAT (黄嘌呤氧化酶抑制剂)BMS754807 (IGF-1R抑制剂)IRS1抗体(小鼠单抗)PHOSPHO-IRS1(SER302)抗体(小鼠单抗)NVP-ADW742 (IGF-1R抑制剂)GLUCOSAMINE (胰岛素抵抗诱导剂)NVP-AEW541 (IGF-1R抑制剂)PHOSPHO-IRS1(SER307)抗体(兔多抗)
AMPK Signaling
AMPK ALPHA 1 RABBIT MONOCLONAL ANTIBODYABCG1兔单克隆抗体CYCLIN A2 RABBIT MONOCLONAL ANTIBODYAICAR (AMPK激活剂, >98%)AICAR (AMPK激活剂, >99%)AMPK BETA 1 RABBIT MONOCLONAL ANTIBODYAnti-Insulin antibody, Mouse monoclonalMETFORMIN (LKB1-AMPK激活剂)IBMX (PDES抑制剂)SIMVASTATIN (HMG-COA REDUCTASE抑制剂)
Warburg Effect
VDAC1 RABBIT MONOCLONAL ANTIBODYGLUCOSE TRANSPORTER GLUT1 RABBIT MONOCLONAL ANTIBODYLACTATE DEHYDROGENASE RABBIT MONOCLONAL ANTIBODY糖原合成酶兔单克隆抗体PGK1 RABBIT MONOCLONAL ANTIBODYAnti-Hexokinase-1 antibody produced in rabbitENASIDENIB (DEHYDROGENASE抑制剂)
Hypoxdia Signaling
HO-1兔单克隆抗体ISOCITRATE DEHYDROGENASE/IDH1 MOUSE MONOCLONAL ANTIBODYHIF-1 BETA RABBIT MONOCLONAL ANTIBODYHIF-1Α抗体(小鼠单抗)GLUTATHIONE PEROXIDASE 1 MOUSE MONOCLONAL ANTIBODYPARK7/DJ1 RABBIT MONOCLONAL ANTIBODYPHOSPHO-NRF2 (SER40) RABBIT MONOCLONAL ANTIBODYFERRITIN RABBIT MONOCLONAL ANTIBODYHIF-1Α抗体NQO2 RABBIT MONOCLONAL ANTIBODYPHD1兔单克隆抗体MYOGLOBIN RABBIT MONOCLONAL ANTIBODY
Fatty acid metabolism
RVX-208 (BET BROMODOMAIN抑制剂)PHOSPHO-ACC(SER79)抗体(兔多抗)
Glucose metabolism
LY2606368 (CHK抑制剂)CANAGLIFLOZIN (SGLT抑制剂)IPRAGLIFLOZIN (SGLT2抑制剂)
Hypoxia Signaling
TH-302 (低氧激活前药)CARIPORIDE (NHE抑制剂)
Transmembrane Transporters
CFTRINH 172 (CFTR抑制剂)TARIQUIDAR (P-GP抑制剂)ELACRIDAR (P-GP抑制剂)RBC8 (GTPASES RALA抑制剂)IVACAFTOR (CFTR激活剂)
Microtubule Dynamics
微管蛋白(抗原)TACC3 兔单克隆抗体Anti-alpha Tubulin抗体S100 BETA RABBIT MONOCLONAL ANTIBODYΒ微管蛋白兔单克隆抗体DYNLL1 RABBIT MONOCLONAL ANTIBODYMKLP1 兔单克隆抗体AURORA B RABBIT MONOCLONAL ANTIBODYS100A4 RABBIT MONOCLONAL ANTIBODYANTI-BETA I TUBULIN抗体MAP1B(MAP5)抗体SIRREAL2 (SIRT2抑制剂)TUBULIN抗体(小鼠单抗)SB-743921 (KSP抑制剂)AGK2 (SIRT2抑制剂)CABAZITAXEL (MICROTUBULE ASSOCIATED抑制剂)EPOTHILONE A (MICROTUBULE ASSOCIATED抑制剂)GSK923295 (CENP-E抑制剂)
Actin Dynamics
ROCK1 RABBIT POLYCLONAL ANTIBODYPHOSPHO-AMPKΑ(THR172)ANTIBODYLSP1 RABBIT MONOCLONAL ANTIBODYCDC42 RABBIT MONOCLONAL ANTIBODYVASP RABBIT MONOCLONAL ANTIBODYRADIXIN RABBIT MONOCLONAL ANTIBODYCORTACTIN RABBIT MONOCLONAL ANTIBODYMYOSIN LIGHT CHAIN 2 RABBIT MONOCLONAL ANTIBODYPLECTIN RABBIT MONOCLONAL ANTIBODYMOESIN RABBIT MONOCLONAL ANTIBODYP16 ARC RABBIT MONOCLONAL ANTIBODYWASF2 RABBIT MONOCLONAL ANTIBODYCALDESMON RABBIT MONOCLONAL ANTIBODYMYOSIN LIGHT CHAIN KINASE RABBIT MONOCLONAL ANTIBODYCMET RABBIT POLYCLONAL ANTIBODYPHOSPHO-AMPKΑ(THR172)抗体(兔单抗)K-115 (ROCK抑制剂)RKI-1447 (ROCK抑制剂)
Adherens Junction Dynamics
ICAM1 RABBIT POLYCLONAL ANTIBODYZO1 RABBIT POLYCLONAL ANTIBODYEPCAM MOUSE MONOCLONAL ANTIBODYVCAM1 RABBIT MONOCLONAL ANTIBODYCALPAIN 1 LARGE SUBUNIT抗体(兔多抗)INTEGRIN Β1/CD29 RABBIT POLYCLONAL ANTIBODYE-CADHERIN MOUSE MONOCLONAL ANTIBODYFAK RABBIT MONOCLONAL ANTIBODYCALPAIN 1 LARGE SUBUNIT ANTIBODYINTEGRIN ALPHA 6 RABBIT MONOCLONAL ANTIBODYN-CADHERIN RABBIT POLYCLONAL ANTIBODY
Translational Control
ARF1 RABBIT MONOCLONAL ANTIBODYEIF5A RABBIT MONOCLONAL ANTIBODYPHOSPHO-ATF2 (THR71) RABBIT MONOCLONAL ANTIBODYRPS3 RABBIT MONOCLONAL ANTIBODY血管紧张素I抗体YB1 RABBIT MONOCLONAL ANTIBODY苯乙醇胺甲基转移酶抗体胱抑素C抗体金属蛋白酶抑制因子RECK抗体L-瓜氨酸抗体脱氧核糖核酸酶2抗体基质金属蛋白酶13抗体半胱胺酸蛋白酶蛋白-12抗体PI3 Kinase p110 beta脱氧鸟苷激酶抗体PHOSPHO-EIF-2A (SER51) RABBIT MONOCLONAL ANTIBODYATF5 RABBIT MONOCLONAL ANTIBODYRPS20 RABBIT MONOCLONAL ANTIBODY
elF2 pathway
PHOSPHO-PKR (THR446) RABBIT MONOCLONAL ANTIBODYPHOSPHO-PERK(THR980)抗体(兔单抗)PKR RABBIT MONOCLONAL ANTIBODY
Ubiquitin/Proteasome
PCNA RABBIT MONOCLONAL ANTIBODY泛素兔单克隆抗体VCP RABBIT POLYCLONAL ANTIBODYRNF20 RABBIT MONOCLONAL ANTIBODYUBIQUITIN RABBIT POLYCLONAL ANTIBODYM6PR RABBIT MONOCLONAL ANTIBODYAnti-Ubiquitin抗体PHOSPHO-BRCA1(SER1423)抗体(兔多抗)CATHEPSIN D RABBIT MONOCLONAL ANTIBODYCDC34 RABBIT MONOCLONAL ANTIBODYNEDD4-2 RABBIT MONOCLONAL ANTIBODYUBIQUITIN D RABBIT MONOCLONAL ANTIBODYCD63 RABBIT MONOCLONAL ANTIBODYPCNA MOUSE MONOCLONAL ANTIBODYBORTZEOMIB (PS-341) (PROTEASOME抑制剂)TELAPREVIR (HCV PROTEASE抑制剂)CARFILZOMIB (PROTEASOME抑制剂)EPOXOMICIN (20S PROTEASOME抑制剂)
Protein Folding
BIP抗体(兔多抗)CALNEXIN抗体(小鼠单抗)CALNEXIN RABBIT MONOCLONAL ANTIBODYERP44抗体(羊多抗)IRE1Α抗体(兔多抗)GRP78 RABBIT POLYCLONAL ANTIBODYPDI抗体(兔多抗)ERP44抗体(兔单抗)
内参抗体
Anti-ACTA2 Rabbit Monoclonal Antibody兔抗PAPPA-AS1多克隆抗体Α-SMOOTH MUSCLE ACTIN RABBIT POLYCLONAL ANTIBODYACTIN抗体(小鼠单抗)3-磷酸甘油醛脱氢酶单克隆抗体(内参抗体)细胞色素C氧化酶 IV亚型小鼠抗GAPDH单克隆抗体MONOCLONAL ANTI-GAPDH 小鼠抗ANTI-TRAIL抗体细胞色素C氧化酶 IV亚型MONO-METHYL-HISTONE H3 (LYS18) RABBIT MONOCLONAL ANTIBODYANTI-GAPDH 抗体ANTI-Β-TUBULIN 抗体GAPDH ANTIBODYDI-METHYL-HISTONE H3(LYS9)抗体(兔多抗)Tubulin alpha antibodyHISTONE H3抗体(兔多抗)ACTBPolyclonal Antibody
标签抗体
ANTI-MYC TAG MOUSE MONOCLONAL ANTIBODY绿色荧光蛋白ANTI-HA TAG RABBIT POLYCLONAL ANTIBODYGST抗体(小鼠单抗)绿色荧光蛋白GFP MOUSE MONOCLONAL ANTIBODY谷胱甘肽S转移酶单克隆抗体绿色荧光蛋白RAT ANTI C-MYC绿色荧光蛋白HA抗体(小鼠单抗)ANTI-C-MYC抗体PERCP标记小鼠抗人CD3单克隆抗体ANTI-C-MYC TAG RABBIT POLYCLONAL ANTIBODYANTI-HA TAG抗体APC标记小鼠抗人CD3单克隆抗体
细胞器标志抗体
RAB5抗体异硫氰酸荧光素标记ANTI-AIF抗体(标记抗体)磷酸化CENP-A(SER7位点)抗体RAB5抗体(小鼠单抗)CYTOKERATIN 5 RABBIT MONOCLONAL ANTIBODYPHOSPHO-CENP-A(SER7)抗体(兔多抗)CENP-A抗体(兔多抗)YY1 RABBIT MONOCLONAL ANTIBODYAIF抗体(兔多抗)NESTIN抗体(小鼠单抗)
细胞标志抗体
NESTIN RABBIT MONOCLONAL ANTIBODYCD13兔单克隆抗体小鼠抗GFAP单克隆抗体PROSTATE SPECIFIC ANTIGEN RABBIT MONOCLONAL ANTIBODYALDH1A1 RABBIT MONOCLONAL ANTIBODYGFAP抗体(小鼠单抗)Anti-ATP1b2/Na+K+ATPaseNEUN RABBIT MONOCLONAL ANTIBODYANTI-NESTIN抗体NESTIN抗体DESMIN RABBIT MONOCLONAL ANTIBODYANTI-GFAP抗体NEURONAL CLASS III Β-TUBULIN(TUJ1)抗体(小鼠单抗)
对照lgG
猪IGG干粉山羊IGG干粉羊抗兔IGG–FITCBSA-FITC豚鼠IGG干粉(亲和纯化) 兔IGG牛IGG干粉IGG4 RABBIT MONOCLONAL ANTIBODY羊抗人白蛋白–FITC兔抗人IGA-RBITC人IGG-FITC马IGG干粉兔抗猴IGG–FITC兔IGG干粉大鼠IGG干粉狗IGG干粉羊IGG小鼠IGG干粉
其他一抗
CASPASE 5 RABBIT MONOCLONAL ANTIBODY雷尼株单抗PHOSPHO-RPA32/RPA2 (THR21) RABBIT MONOCLONAL ANTIBODYDNA损伤修复基因XRCC9抗体脂肪酰基辅酶A还原酶1抗体ANTI-IGE抗体磷酸化表皮生长因子受体兔单克隆抗体DNA酶1样蛋白1抗体DNA拓扑异构酶3-Β1抗体血管紧张素Ⅱ抗体AICDA antibodyAGTR1 antibodyAGK antibodyADORA3 antibodyADM AntibodyADCY8 antibodyACTC1 AntibodyACOX2 Antibody
NALE抗体
ANTI-CD3, APC
Sampler kit
Phospho-Histone H3 (Mitotic Marker) Antibody Sampler KitNuRD Complex Antibody Sampler KitIntegrin Antibody Sampler KitEpithelial-Mesenchymal Transition (EMT) Antibody Sampler Kitc-Kit Antibody Sampler KitTranslation Initiation Complex Antibody Sampler KitRb Antibody Sampler KitInitiator Caspases Antibody Sampler KitRetinoic Acid and Retinoid X Receptors Antibody Sampler KitParkinson's Research Antibody Sampler KitHippo Signaling Antibody Sampler KitER and Golgi-Associated Marker Proteins Antibody Sampler KitAcetyl-Histone Antibody Sampler KitDNA Damage Antibody Sampler KitUbiquitin E3 Ligase Complex Antibody Sampler KitER Protein Folding Antibody Sampler KitCellular Localization IF Antibody Sampler KitAutophagy Antibody Sampler Kit
WB一抗
果桃Α-L-阿拉伯呋喃糖苷酶抗体CHK2 细胞周期检测点激酶2抗体AGPAT1 溶血磷脂酰基转移酶抗体
大鼠
MOUSE ANTI RAT NEUROFILAMENT 200kDaMOUSE ANTI RAT CALCITONIN RECEPTOR (C1b ISOFORM)Rat Brain Cortex Neurons amp, 4M cellsRat Tyr Hydroxylase Pure TOH A1 100ugRat Macrophage Subset PE HIS36 200ugRat mGluR1Alp Pure G209-488 100ugRat IgG2a Pure B46-7 500ugRat Calvariae OsteoblastsRAT ANTI RAT MHC CLASS II I-AbRat Brain HC Astrocytes amp, 1 mil cellsMOUSE ANTI RAT CD8 ALPHA:Low EndotoxinRABBIT ANTI RAT 5-ALPHA REDUCTASE TYPE 2MOUSE ANTI RAT RETICULUM CELLSMOUSE ANTI RAT CD45RCRat Retinal CellsRat Ig Lam Light Chain PE B46-5 200ugRat Hypothalamic NeuronsRABBIT ANTI RAT ANDROGEN BINDING PROTEIN
单抗
P53(WT-P53) (D2F7) 肿瘤抑制基因野生型P53单抗ANTI-CD20抗体MOUSE ANTI C-MYCAnti-EGFR AntibodyANTI-PD-L1抗体Rabbit Anti-Murine CTLA-4Anti-IL-18 AntibodyANTI-CD3Anti-IL-18 AntibodyHamster Anti Mouse CD28 ANTI-LAMIN B1抗体ANTI-PARKIN抗体ANTI-RAT BOKB淋巴细胞粘附分子CD22抗体Anti-COX1 / Cyclooxygenase 1抗体辣根过氧化物酶标记 肿瘤坏死因子抗体ANTI-CD28抗体小鼠抗β-Tubulin单克隆抗体
对照IgG
鼠IGG
多抗
兔抗IL6R多克隆抗体Anti-Caspase 4ANTI-MMP9抗体单羧酸转运蛋白-1抗体ANTI-BETA II TUBULIN抗体兔抗马多克隆抗体生物素标记 肿瘤坏死因子抗体ANTI-HUMAN IL-12BAAT 长链脂肪酸酰基辅酶A水解酶抗体C型钠尿肽抗体ANTI-SOX-2ANTI-HUMAN IL-6Rabbit Anti-Human IL-6ANTI-HISTONE H3 (PHOSPHO T118)抗体ANTI-BADAnti-laminin抗体标签抗体HA,多克隆抗体,兔抗,红细胞凝集素表面抗原决定簇A型流感病毒H9N1神经氨酸酶型抗体
临床级别
亲和素Cd45RaCD22 (BL-CAM)CD20(抗体)CD10单抗CD45 (LEUKOCYTECOMMON ANTIGEN)血小板内皮细胞黏附分子-1 (抗体)二肽酶人血清IGM(液体)70-80%纯度小鼠白细胞介素13酶联免疫试剂盒
脂肪酰辅酶A还原酶2抗体一氧化氮合成酶-1抗体(神经型)NHMC-Mesangial Cells MsGM, cryo ampMOUSE ANTI HUMAN MELANOCYTE CELL SURFACE ANTIGENMOUSE ANTI HUMAN LYSOZYMEMOUSE ANTI HUMAN BETA ENDORPHINHuman Dental Pulp Stem Cells 1MHu Msc LineageE Cktl SetHu IL-5 Pure JES1-39D10 500ugD-SAEC-Asthma, cryoampSHEEP ANTI HUMAN PROTEOGLYCAN 1 (41-54 OF PRECURSOR)MOUSE ANTI HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORHu TGF-BTA1 PE-CF594 TW4-9E7 50TstHu STING PE-CF594 T3-680 50TstHu IgD Biotin IA6-2 500ugHu CD64 PE-Cy7 10.1 50TstHu CD16 BUV496 3G8 25TstHu CD140b Pure 28 50ug
小鼠
Ms IL-2 Pure JES6-5H4 100ugMs H2-M3 Pure 130 100ugMs CD45 IHC Pure 30-F11 1mLMs CD34 PE RAM34 200ugMs CD4 Pacific Blue RM4-5 100ugRABBIT ANTI MOUSE CAD (aa205-222)Ms Ig HRP Dtec KitMs CD210 Pure 1B1.3a 500ugMouse C57 Cortex Neurons Cryo, 4 milMs KLRG1 PE-CF594 2F1 50ugMs GRAIL Pure H11-744 100ugGOAT ANTI MOUSE KAPPA LIGHT CHAIN:Texas RedMs VBta 14 TCR Biotin 14-2 250ugMs HSC SLAM CODE PanelMs CD74 Pure In-1 500ugMs Panen Cell Ag Pure MECA-32 500ugMs IgG PSFP Pure 100ugMs CSM Lyoplate Screening Panel
Pig IFN-Gma Biotin P2C11 500ugANTI-ARMENIAN HAMSTER IGG PE 200 UGNORMAL MOUSE SERUM 500 ULCALCEIN BLUE AM VIABILITY DYE 1 MGPig IgM Pure F008-1629 500ugDRAQ5 200 ULINDO-1 AM CALCIUM SENSOR DYE 1 MG
Regulation of Apoptosis
PUMA RABBIT MONOCLONAL ANTIBODYCASPASE-8抗体半胱胺酸蛋白酶蛋白-7抗体CASPASE-3抗体(兔多抗)CYTOCHROME C RABBIT MONOCLONAL ANTIBODYLKB1抗体(兔多抗)Bim兔单克隆抗体HTRA2/OMI 兔单克隆抗体LKB1抗体Caspase-6抗体CASPASE-6 P18 RABBIT MONOCLONAL ANTIBODYDAXX RABBIT MONOCLONAL ANTIBODYP73 RABBIT MONOCLONAL ANTIBODYApaf-1兔单克隆抗体CASPASE 3 (ACTIVE) RABBIT MONOCLONAL ANTIBODYCASPASE-3抗体P35/P25抗体TRAM-34 (POTASSIUM CHANNEL抑制剂)
Inhibition of Apoptosis
HSP90抗体(小鼠单抗)PHOSPHO-HSP27 (SER82) RABBIT MONOCLONAL ANTIBODYSURVIVIN 兔单克隆抗体磷酸化STAT5(Tyr694)兔单克隆抗体HSP60 MOUSE MONOCLONAL ANTIBODYPHOSPHO-CDC37 (SER13) RABBIT MONOCLONAL ANTIBODYHSPA4 RABBIT MONOCLONAL ANTIBODY兔抗STAT6多克隆抗体hsp105兔单克隆抗体HSP70抗体(小鼠单抗)PHOSPHO-STAT5 (TYR694) RABBIT MONOCLONAL ANTIBODYHSP20 RABBIT MONOCLONAL ANTIBODYSTAT5A RABBIT MONOCLONAL ANTIBODYSTAT5B RABBIT MONOCLONAL ANTIBODY磷酸化HSP27 (pSer82)兔单克隆抗体TNFAIP3 RABBIT MONOCLONAL ANTIBODYXIAP抗体(兔多抗)SURVIVIN抗体(兔单抗)
Death Receptor Signaling
MLKL RABBIT MONOCLONAL ANTIBODYPARP (裂解) 单克隆抗体ALPHA SMOOTH MUSCLE ACTIN RABBIT MONOCLONAL ANTIBODYCLEAVED PARP RABBIT MONOCLONAL ANTIBODYPARP RABBIT MONOCLONAL ANTIBODYOLAPARIB (PARP抑制剂)PARP抗体(兔多抗)
Mitochondrial Control of Apoptosis
BCL-XL抗体(兔单抗)BCL2A1 RABBIT MONOCLONAL ANTIBODYPBR RABBIT MONOCLONAL ANTIBODYBad 抗体BAX RABBIT MONOCLONAL ANTIBODYBAX 抗体BAK抗体(兔多抗)PHOSPHO-BCL-2(SER70)抗体Bak 抗体TMS1兔单克隆抗体MCL1 RABBIT MONOCLONAL ANTIBODYBCL-XL 抗体AIF 抗体DIABLO 抗体AIF RABBIT MONOCLONAL ANTIBODYTMS1 MONOCLONAL ANTIBODYPHOSPHO-BCL-2(SER70)抗体(兔单抗)PHOSPHO-BAD(SER112)抗体
Autophagy Signaling
MAP1LC3A RABBIT MONOCLONAL ANTIBODYLC3B抗体(兔多抗)SEQUESTOSOME-1 MOUSE MONOCLONAL ANTIBODYATG5 RABBIT MONOCLONAL ANTIBODYAnti-LC3B antibody, Mouse monoclonalATG9A RABBIT MONOCLONAL ANTIBODYAnti-Autophagy protein 7 / ATG7Rabbit anti APG7, C-term.LAMP2A RABBIT MONOCLONAL ANTIBODYGSK2578215A (LRRK2抑制剂)SMER28 (AUTOPHAGY增强剂)ATG7抗体(兔多抗)SPAUTIN-1 (AUTOPHAGY抑制剂)
Protein Acetylation
MGMT RABBIT POLYCLONAL ANTIBODYSIRT1 兔单克隆抗体SIRT5 兔单克隆抗体HDAC7抗体(小鼠单抗)HDAC6 多克隆抗体SIRT1/SIR2抗体HDAC7 兔单克隆抗体SIRT1/SIR2抗体(兔多抗)单甲基组蛋白 H3 (LYS36) 兔单克隆抗体SIRT2 兔单克隆抗体PHOSPHO-SIRT1 (SER47) RABBIT MONOCLONAL ANTIBODYHDAC4鼠单克隆抗体HDAC1 多克隆抗体HDAC4抗体(小鼠单抗)HDAC3抗体HDAC8 兔单克隆抗体单/二甲基组蛋白 H3 (LYS79) 兔单克隆抗体HDAC3抗体(小鼠单抗)
Histone Methylation
DI-METHYL-HISTONE H3(LYS9)抗体磷酸化组蛋白 H2A.X (139位) 兔单克隆抗体PRMT5 鼠单克隆抗体ANTI-HISTONE H3 (DI METHYL K4)抗体组蛋白 H2A 多克隆抗体PHOSPHO-HISTONE H3(SER10)抗体乙酰组蛋白H2A (LYS9) 兔单克隆抗体PRMT5 RABBIT MONOCLONAL ANTIBODYHISTONE H3抗体DI-METHYL-HISTONE H3(LYS4)抗体磷酸化组蛋白 H1.3/ H1.4 (THR17) 兔单克隆抗体组蛋白 H2A.Z 兔单克隆抗体NSD3 兔单克隆抗体BIX01294 (HISTONE METHYLTRANSFERASE抑制剂)HISTONE H2A抗体(兔多抗)PEMETREXED (DHFR抑制剂)AG-120 (IDH1抑制剂)MI-3 (HISTONE METHYLTRANSFERASE抑制剂)
G1/S Checkpoint
Cyclin E1 Rabbit Monoclonal AntibodyCDK4兔单克隆抗体CDK6抗体(小鼠单抗)PHOSPHO-CHK2(THR68)抗体(兔多抗)CDK6抗体P27 KIP 1 RABBIT MONOCLONAL ANTIBODYCYCLIN D1 RABBIT POLYCLONAL ANTIBODYP21抗体(小鼠单抗)PHOSPHO-ATM(SER1981)抗体(小鼠单抗)P16INK4A RABBIT MONOCLONAL ANTIBODYCDK2 RABBIT MONOCLONAL ANTIBODYPHOSPHO-ATM(SER1981)抗体PHOSPHO-CHK2(THR68)抗体Cyclin E2 Rabbit Monoclonal AntibodyCHOP抗体P27抗体CDC7 KINASE RABBIT MONOCLONAL ANTIBODYPHOSPHO-CDK2 (TYR15) RABBIT MONOCLONAL ANTIBODY
Crosstalk Between Protein Modification
SHP1 RABBIT MONOCLONAL ANTIBODYSHP2 RABBIT MONOCLONAL ANTIBODYPHOSPHO-SHP2 (TYR542) RABBIT MONOCLONAL ANTIBODYPIM1 RABBIT MONOCLONAL ANTIBODYCDK9 RABBIT MONOCLONAL ANTIBODY
G2M/DNA Damage Checkpoint
CDC23 RABBIT MONOCLONAL ANTIBODYPHOSPHO-P53(SER15)抗体Anti-phospho-p95/NBS1 (pSer343) antibody produced in rabbit兔抗TOP2A多克隆抗体PHOSPHO-AURORA抗体(兔单抗)P63 RABBIT MONOCLONAL ANTIBODY磷标记-P53 (THR55) 兔单克隆抗体TOP2A RABBIT POLYCLONAL ANTIBODYPHOSPHO-AURORA抗体P53抗体(小鼠单抗)PHOSPHO-P53(SER15)抗体(兔多抗)FANCD2 RABBIT MONOCLONAL ANTIBODYDNA PKCS RABBIT MONOCLONAL ANTIBODYCDK1 RABBIT POLYCLONAL ANTIBODYANTI-P63抗体MSH6 RABBIT POLYCLONAL ANTIBODYPMS2 RABBIT MONOCLONAL ANTIBODYUBC9 RABBIT MONOCLONAL ANTIBODY
MAPK/Erk in Growth & Differentiation
SELUMETINIB (MEK抑制剂)ESTROGEN RECEPTOR Α抗体(兔单抗)FR 180204 (ERK抑制剂)PHA-665752 (C-MET抑制剂)PHOSPHO-ESTROGEN RECEPTOR Α(SER118)抗体(兔单抗)PHOSPHO-RSK1/P90RSK(SER380)抗体(兔单抗)ANA-12 (TRK RECEPTOR拮抗剂)RSK1/P90RSK抗体(兔多抗)U0126 (MEK1/2抑制剂)COBIMETINIB (MEK抑制剂)PD0325901 (MEK抑制剂)BINIMETINIB (MEK抑制剂)CRIZOTINIB (C-MET抑制剂)VX745 (P38 MAPK抑制剂)AS703026 (MEK抑制剂)SGX-523 (C-MET抑制剂)TIVANTINIB (C-MET抑制剂)
MAPK/Erk in GPCR Signaling
PD 98, 059 (MAPKK抑制剂)PP121 (PDGFR抑制剂)H-89 (PKA抑制剂)GW5074 (RAF抑制剂)KT5823 (PKG抑制剂)SORAFENIB (RAF抑制剂)
SAPK/JNK Signaling
PHOSPHO-MEK1 (SER298) RABBIT MONOCLONAL ANTIBODY血管紧张素II受体样蛋白1抗体JNK1/2/3抗体PHOSPHO-HSF1 (SER326) RABBIT MONOCLONAL ANTIBODYPHOSPHO-JNK/SAPK抗体(小鼠单抗)ANISOMYCIN (JNK激活剂)JNK/SAPK抗体(兔多抗)
p38 MAPK Signaling
丝裂原活化蛋白激酶P38(抗体)PHOSPHO-TAU (SER396) RABBIT MONOCLONAL ANTIBODYPHOSPHO-MSK1 (SER376) RABBIT MONOCLONAL ANTIBODYPHOSPHO-STAT1 (SER727) RABBIT MONOCLONAL ANTIBODYSTAT1 α 兔单克隆抗体STAT-1 Α/Β RABBIT POLYCLONAL ANTIBODYP44/42 MAPK抗体(兔多抗)VX-702 (P38 MAPK抑制剂)PHOSPHO-P38 MAPK抗体(小鼠单抗)PHOSPHO-P44/42 MAPK抗体(小鼠单抗)LOSMAPIMOD (P38 MAPK抑制剂)P38 MAPK抗体(小鼠单抗)PD169316 (P38 MAPK抑制剂)SB239063 (P38 MAPK抑制剂)
PI3K/Akt Signaling
PHOSPHO-AKT1 (SER473) RABBIT MONOCLONAL ANTIBODYPHOSPHO-AKT1 (THR450) RABBIT MONOCLONAL ANTIBODYPHOSPHO-GSK-3Α/Β (TYR216/279) RABBIT MONOCLONAL ANTIBODYFOXO4抗体(兔多抗)IM-12 (GSK-3抑制剂)OKADAIC ACID钾盐(PP1和PP2A抑制剂)TGX221 (PI3K抑制剂)PHOSPHO-FOXO1 (THR24)/FOXO3A(THR32)抗体(兔多抗)TRICIRIBINE (AKT抑制剂)GW9662 (PPAR拮抗剂)PHOSPHO-AKT(THR308)抗体(兔多抗)PHOSPHO-AKT(SER473)抗体(兔多抗)R428 (AXL抑制剂)SC79 (AKT激活剂)PILARALISIB (PI3K抑制剂)TDZD-8 (GSK-3抑制剂)AZD5363 (AKT抑制剂)MK2206 (AKT抑制剂)
mTOR Signaling
RAPAMYCIN (FRAP/MTOR抑制剂)PP242 (MTOR抑制剂)TORIN 1 (MTOR抑制剂)LY303511 (MTOR抑制剂)AZD8055 (MTOR抑制剂)MTOR抗体(小鼠单抗)TEMSIROLIMUS (MTOR抑制剂)
Jak/Stat:1L-6 Signaling
JAK2 RABBIT MONOCLONAL ANTIBODYPACRITINIB (JAK抑制剂)PHOSPHO-JAK2 (TYR1007/1008) RABBIT MONOCLONAL ANTIBODYPHOSPHO-STAT3 (TYR705) RABBIT MONOCLONAL ANTIBODYPHOSPHO-STAT3 (SER727) RABBIT MONOCLONAL ANTIBODYSTAT3 RABBIT MONOCLONAL ANTIBODYIL-6 MOUSE MONOCLONAL ANTIBODY
NF-kB Signaling
IKKΑ RABBIT POLYCLONAL ANTIBODYNF-ΚB P65 RABBIT POLYCLONAL ANTIBODYIKB BETA RABBIT MONOCLONAL ANTIBODYMCSF RABBIT MONOCLONAL ANTIBODYANTI-NF-KB P65 (PHOSPHO S316)抗体IKB-Α抗体(兔多抗)IFNAR1 RABBIT MONOCLONAL ANTIBODYANTI-NF-KB P65抗体COX2/CYCLOOXYGENASE 2 RABBIT MONOCLONAL ANTIBODY
Toll-Like Receptor Signaling
IRF7 RABBIT MONOCLONAL ANTIBODYHMGB1 RABBIT POLYCLONAL ANTIBODYIRF3 RABBIT MONOCLONAL ANTIBODYTLR7 RABBIT POLYCLONAL ANTIBODYZK811752 (CCR1拮抗剂)
B Cell Receptor Signaling
SHIP RABBIT MONOCLONAL ANTIBODYBTK RABBIT MONOCLONAL ANTIBODYCD19 MOUSE MONOCLONAL ANTIBODYPHOSPHO-BTK (TYR223) RABBIT MONOCLONAL ANTIBODYR406 (SYK抑制剂)ONO-4059 ANALOGUE (BTK抑制剂)AVL292 (BTK抑制剂)R406 (FREE BASE) (SYK抑制剂)CGI-1746 (BTK抑制剂)CHIR-090 (LPXC抑制剂)IBRUTINIB (BTK抑制剂)RN486 (BTK抑制剂)
T-Cell Receptor Signaling
CD9 RABBIT POLYCLONAL ANTIBODYANTI-CD86抗体ANTI-HUMAN CD152CCR2 RABBIT MONOCLONAL ANTIBODYCD44 MOUSE MONOCLONAL ANTIBODYCD31 RABBIT POLYCLONAL ANTIBODYCD38 RABBIT MONOCLONAL ANTIBODYCD90 RABBIT MONOCLONAL ANTIBODYCAMKII RABBIT MONOCLONAL ANTIBODYASCOMYCIN (大环内酯类免疫抑制剂)PIMECROLIMUS (CALCINEURIN抑制剂)ZANAMIVIR (NEURAMINIDASE抑制剂)
Antimicrobial Signaling
TRAMETINIB (MEK抑制剂)ANTI-CD68抗体BPI RABBIT MONOCLONAL ANTIBODYLYSOZYME RABBIT MONOCLONAL ANTIBODYPBP RABBIT MONOCLONAL ANTIBODYANIDULAFUNGIN (GLUCAN SYNTHASE抑制剂)CASPOFUNGIN ACETATE (Β-1,3-GLUCAN SYNTHASE抑制剂抑制剂)LED209 (QSEC抑制剂)PIRODAVIR (HRV CAPSID-BINDING抑制剂)PSI-6206 (HCV抑制剂)SOLITHROMYCIN (抗菌药)BMS626529 (HIV抑制剂)PA-824 (抗肺结核药)NESBUVIR (HCV抑制剂)
Jak/Stat:IL-6 Signaling
ANTI-IL-12抗体ABT-333 (HCV抑制剂)CANERTINIB (EGFR抑制剂)BARICITINIB (JAK抑制剂)SIMEPREVIR (HCV抑制剂)AG 490 (JAK抑制剂)SGI-1776 (PIM抑制剂)LAPATINIB (EGFR抑制剂)MK5172 (HCV抑制剂)CL-387785 (EGFR抑制剂)WP1066 (JAK抑制剂)XL019 (JAK抑制剂)AT9283 (JAK抑制剂)NSC 74859 (STAT抑制剂)RUXOLITINIB (JAK抑制剂)PD153035 (EGFR抑制剂)
NF-κB Signaling
LPS (TLR4激活剂)NF-ΚB P65抗体(兔多抗)PDTC (NF-ΚB抑制剂/抗氧化剂)BAY 11-7085 (IΚB/IKK抑制剂)IKKΑ抗体(兔多抗)BAY 11-7082 (NF-ΚB抑制剂)CURCUMIN (COX抑制剂)NF-ΚB激活-核转运检测试剂盒PHOSPHO-NF-ΚB P65(SER536)抗体(兔单抗)LPS (ULTRAPURE, TLR4激活剂)PHOSPHO-IKKΑ/Β(SER176/180)抗体(兔单抗)WS6 (IΚB/IKK抑制剂)
Hippo Signaling Pathway
MST2 RABBIT MONOCLONAL ANTIBODYAGR2 RABBIT MONOCLONAL ANTIBODY
ESC Pluripotency and Differentiation
OOEP RABBIT POLYCLONAL ANTIBODYMATER RABBIT POLYCLONAL ANTIBODYOCT-4 MOUSE MONOCLONAL ANTIBODYISLET 1 RABBIT MONOCLONAL ANTIBODY
Stem Cell & Lineage Markers
GPR49/LGR5 RABBIT POLYCLONAL ANTIBODYMUSASHI 1 RABBIT MONOCLONAL ANTIBODYSCF RABBIT MONOCLONAL ANTIBODYLGR5/GPR49 RABBIT MONOCLONAL ANTIBODY
Wnt/β-Catenin Signaling
SOX9 RABBIT MONOCLONAL ANTIBODYΒ-CATENIN抗体(兔多抗)APC RABBIT MONOCLONAL ANTIBODYΒ-CATENIN RABBIT POLYCLONAL ANTIBODYDKK1 RABBIT MONOCLONAL ANTIBODYΒ-CATENIN MOUSE MONOCLONAL ANTIBODY兔抗CDK8单克隆抗体ETC-159 (WNT抑制剂)IWP-2 (WNT/Β-CATENIN抑制剂)AP26113 (ALK抑制剂)ICG001 (WNT/Β-CATENIN抑制剂)
Notch Signaling
NOTCH 1 RABBIT MONOCLONAL ANTIBODYTCF7L2 RABBIT MONOCLONAL ANTIBODYHES1 RABBIT MONOCLONAL ANTIBODYc-Kit兔单克隆抗体TCF3 RABBIT MONOCLONAL ANTIBODYYO-01027 (GAMMA -SECRETASE抑制剂)
Hedgehog Signaling
SMAD4 RABBIT MONOCLONAL ANTIBODYYAP1 RABBIT MONOCLONAL ANTIBODYBMP2 RABBIT POLYCLONAL ANTIBODYBMI1 MOUSE MONOCLONAL ANTIBODYPHOSPHO-YAP1 (SER127) RABBIT MONOCLONAL ANTIBODY
TGF-β Signaling
PHOSPHO-GSK-3Β (SER 9) RABBIT MONOCLONAL ANTIBODYPHOSPHO-SMAD2 (SER250) RABBIT MONOCLONAL ANTIBODYSMAD2 RABBIT MONOCLONAL ANTIBODYPHOSPHO-GSK-3Β(SER9)抗体(兔多抗)SMAD5 RABBIT MONOCLONAL ANTIBODYPHOSPHO-SMAD3 (SER423/425) RABBIT MONOCLONAL ANTIBODYSMAD3 RABBIT MONOCLONAL ANTIBODY胸腺素Β10抗体LDN193189 (TGF-Β/SMAD抑制剂)SB431542 (TGF-Β/SMAD抑制剂)GALUNISERTIB (TGF-Β/SMAD抑制剂)ITD 1 (TGF-Β RECEPTOR抑制剂)
Nuclear Receptor Signaling
KAP1 RABBIT MONOCLONAL ANTIBODYMSI2 RABBIT MONOCLONAL ANTIBODYNUP98抗体(兔单抗)KU70 MOUSE MONOCLONAL ANTIBODYFIBRILLARIN抗体(兔单抗)HISTONE H2B抗体(小鼠单抗)PAX9 RABBIT MONOCLONAL ANTIBODYRHOA RABBIT MONOCLONAL ANTIBODYVAV2 RABBIT MONOCLONAL ANTIBODYHISTONE H4抗体(兔多抗)PHOSPHO-C-MYC (SER62) RABBIT MONOCLONAL ANTIBODYCEBP ALPHA RABBIT MONOCLONAL ANTIBODYFNTB RABBIT MONOCLONAL ANTIBODYPAX6 RABBIT MONOCLONAL ANTIBODYDGCR8 RABBIT MONOCLONAL ANTIBODYASH2L RABBIT MONOCLONAL ANTIBODYKU80 RABBIT MONOCLONAL ANTIBODYGART RABBIT MONOCLONAL ANTIBODY
ErbB/HER Signaling
MUC16 RABBIT MONOCLONAL ANTIBODYELK1 RABBIT MONOCLONAL ANTIBODYHER2/ERBB2 RABBIT POLYCLONAL ANTIBODYPSD95 RABBIT MONOCLONAL ANTIBODYCASPASE-1 RABBIT MONOCLONAL ANTIBODYMUC1 RABBIT MONOCLONAL ANTIBODYHER2/ERBB2抗体(兔多抗)PHOSPHO-HER2/ERBB2(TYR1221/1222)抗体(兔单抗)NERATINIB (HER2抑制剂)GENISTEIN (酪氨酸蛋白激酶抑制剂)AEE788 (NVP-AEE788) (EGFR抑制剂)
Angiogenesis
CAVEOLIN-1 RABBIT MONOCLONAL ANTIBODYEGFR RABBIT MONOCLONAL ANTIBODYMMP14 RABBIT MONOCLONAL ANTIBODYVEGF抗体(兔多抗)VEGF RABBIT POLYCLONAL ANTIBODYANTI-VEGF-C POLYCLONAL ANTIBODYMMP1 RABBIT POLYCLONAL ANTIBODYPHOSPHO-EGFR (TYR1092) RABBIT MONOCLONAL ANTIBODY小鼠抗EGFR单克隆抗体FGFR1 RABBIT MONOCLONAL ANTIBODYMMP11 RABBIT MONOCLONAL ANTIBODYCAVEOLIN-2 RABBIT MONOCLONAL ANTIBODYAXITINIB (VEGFR抑制剂)SUNITINIB (PDGFR抑制剂)R1530 (VEGFR抑制剂)SARACATINIB (SRC抑制剂)VANDETANIB (VEGFR抑制剂)CERITINIB (ALK抑制剂)
Coagulation
ALAS1 RABBIT MONOCLONAL ANTIBODYTISSUE FACTOR RABBIT MONOCLONAL ANTIBODYDABIGATRAN (THROMBIN抑制剂)ELTROMBOPAG (TPOR激动剂)VORAPAXAR (PAR-1拮抗剂)EDOXABAN (FACTOR XA抑制剂)