Rabbit Anti-IGFBP7 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:IGFBP7
IR:Immunogen Range:131-230/282
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:3490
Swiss Prot:Q16270
Source:KLH conjugated synthetic peptide derived from human IGFBP7:131-230/282
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:IGF-BPs form high affinity complexes with both IGF-I and IGF-II and act to control of the distribution, function and activity of IGFs in various cell tissues and body fluids. There are seven named IGF-BPs. IGFBP7 plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGFBP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. IGFBP7 is expressed in a wide range of normal human tissues and it usually shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Dog
Cow
Sheep
仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: IGFBP7;AGM;Angiomodulin;FSTL2;IBP7;IGF binding protein ;RAMSVPS;IBP7_HUMAN;
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