Rabbit Anti-DR6 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:DR6
IR:Immunogen Range:101-200/655
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:27242
Swiss Prot:O75509
Source:KLH conjugated synthetic peptide derived from human DR6/CD358:101-200/655
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
Tissue specificity: Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Cow
Horse
Rabbit
.
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： DR6;TNFRSF 21;BM018;CD358;Death receptor 6;MGC31965;TNFRSF21 protein;TNR21_HUMAN;
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