AZD776

AZD7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2, respectively. It significantly prolonged the median time required for tumor volume doubling in response to gemcitabine and radiation. Together, findings suggest that G(2) checkpoint abrogation and homologous recombination repair inhibition both contribute to sensitization by Chk1 inhibition. Furthermore, they support the clinical use of AZD7762 in combination with gemcitabine and radiation for patients with locally advanced pancreatic cancer.

产品名称: AZD7762

CAS: 860352-01-8

包装：1g, 5g,10g,100g,1000g

含量：99%

上海化成医药化工有限公司

联系人：石先生

电话：13621923966

Shanghai H&C Chemical Co.,Ltd. is a innovative company engaged in organic intermediates, pharmaceutical ingredients, fine chemicals and custom synthesis. H&C have high experience from lab to semiwork and commercial production,and manufacturing team have high experience in cost saving, process improvement and quality control. H&C are high appraised by our customers for excellent quality and good price.