aladdin 阿拉丁 P413892 PLX8394 1393466-87-9 97%

中文名：PLX8394

英文名：PLX8394

纯度：Moligand™，≥97%

货号：P413892

Cas号：1393466-87-9

存储温度：-20°C储存

运输条件：超低温运输

产品介绍：

Information

PLX8394 is a next-generation, orally available, small-moleculeBRAFinhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity.

Targets

BRAF(V600E) (Cell-free assay); BRAF (Cell-free assay); CRAF (Cell-free assay) 3.8 nM; 14 nM; 23 nM

In vitro

PLX8394 is a next-generation, orally available small-molecule BRAFi that does not induce the RAF/MEK/ERK paradoxical activation and blocks signaling from both monomeric BRAF^V600 and dimeric BRAF^{non-V600 protein}.

Cell Research(from reference)

Cell lines：colorectal cancer cell lines 

Concentrations：1 μM 

Incubation Time：6 h 

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