中文名：洛莫司汀
英文名：Lomustine
英文别名：NSC79037, Gleostine, CeeNU, CCNU;N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-urea
纯度：10mM in DMSO
货号：L409232
包装：1ml
Cas号：13010-47-4
存储温度：-80℃储存
产品介绍：
Information
Lomustine (NSC79037, Gleostine, CeeNU, CCNU) inhibits cancer cells by damaging theDNAand stops cells from dividing.
In vitro
Lomustine inhibits the growth of ZR-75-1 and U373 with IC50 of 12 μM and 15 μM, respectively. Lomustine reduces the level of expression of the DNA repair protein O6-alkylguanine-DNA alkyltransferase. Lomustine (420 μM) triggers apoptosis through the mitochondrial pathway via decrease in the level of the anti-apoptosis proteins Bcl-2 and Bcl-xl, respectively, in both medulloblastoma and normal human epithelial and fibroblast cells. Lomustine induces cell cycle delay in G2/M phase in medulloblastoma cells and up-regulates p21 protein level in a p53-independent manner in HFSN1 cells.
In vivo
Lomustine can cause delayed, cumulative dose-related, chronic hepatotoxicity that is irreversible and can be fatal. Lomustine could result in infrequent severe hematological toxicity in cats with spontaneously arising tumors, and the incidence of either grade III or IV neutropenia and thrombocytopenia is 4.1% and 1.0%, respectively. Lomustine trends toward a greater likelihood for progressive neutropenia and statistically significant higher response rates in cats with spontaneously arising tumors.
Cell Data
cell lines：A375 cells
Concentrations：133 μM
Incubation Time：1 hour
Powder Purity:≥98%
查看阿拉丁官网此产品相关对应页面：https://www.aladdin-e.com/zh_cn/L409232.html
关键字： NSC79037, Gleostine, CeeNU, CCNU;N-?(2-?chloroethyl)?-?N'-?cyclohexyl-?N-?nitroso-urea
上海阿拉丁生化科技股份有限公司是A股上市公司（（股票代码：688179），专注于科研试剂的研发、生产和销售，已陆续建立多个工厂和研发中心。作为领军企业，阿拉丁始终坚持质量第一，连续13年被评为“最受欢迎试剂品牌”。
阿拉丁目前常备库存试剂产品品种超过7万种，SKU总数超过46万，产品线涵盖了化学试剂、生化试剂、药靶配体、蛋白质和抗体等多个领域，是国内少数化学试剂到生物试剂全面发展的国产试剂品牌，产品同步发布在我们国内外电商平台。