生物活性Eflornithine(Difluoromethylornithine,DFMO,MDL-71782,RMI-71782,α-difluoromethylornithine)hydrochloridehydrate通过对鸟氨酸脱羧酶的不可逆抑制作用,抑制多胺生物合成。它是一种化疗保护剂,可阻止血管生成。其生物半衰期为8小时。靶点TargetValueOrndecarboxylase体外研究用α-difluoromethyl-Orn处理BY2细胞,抑制其过氧化氢的产生,但并没有发生程序性细胞死亡。体内研究EflornithineistheonlynewmoleculeregisteredforthetreatmentofhumanAfricantrypanosomiasisoverthelast50years.Itisthedrugusedmainlyasaback-upformelarsoprolrefractoryTrypanosomabruceigambiensecases.Insubjectswithexcessive,unwantedfacialhair,eflornithine15%creamissuperiortoplaceboinreducinghairgrowth.After24weeks'treatment,58%ofeflornithineand34%ofplacebosubjectshaveatleastsomeimprovementinfacialhirsutism.Thehairgrowthinhibitoryactivityofeflornithineissignificantlyenhancedwhentheeflornithinecreamisappliedontoamouseskinareapretreatedwithmicroneedles.TreatmentofcoarctationhypertensiveratswitheflornithineresultsinanormalizationofthecontractileintensitytoKCIandnorepinephrineandrelaxationstoacetylcholineby14daysofhypertension.
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