Mouse Fc gamma RIIB / CD32b Protein, His Tag (SPR & BLI & MALS verified)
分子别名(Synonym)
FCGR
表达区间及表达系统(Source)
Mouse CD32b, His Tag (CDB-M52H7) is expressed from human 293 cells (HEK293). It contains AA Thr 40 - Arg 217 (Accession # NP_001070657.1).
Predicted N-terminus: Thr 40
蛋白结构(Molecular Characterization)

This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 22.2 kDa. The protein migrates as 32-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.


背景(Background)
IgG Fc区受体(FcγR)是Ig超家族的成员,在激活或抑制免疫反应中发挥作用。识别出三类人FcγRs:RI(CD64)、RII(CD32)和RIII(CD16),它们产生多种亚型。
人类FcγRII/CD32有三个基因(A、B和C),小鼠FcγRII B有一个基因(CD32B)。CD32是IgG的低亲和力受体。低亲和力免疫球蛋白γFc区受体II-b(FCGR2B)也称为CD32b、FCG2、IGFR2。CD32B在B细胞和髓样树突状细胞上表达。B细胞上CD32B的连接下调了抗体的产生,在某些情况下可能会促进细胞凋亡。树突状细胞上CD32B的共连接抑制成熟并阻断细胞活化。CD32B也可能是恶性肿瘤单克隆抗体治疗的靶点。
关键字: Fc gamma RIIB;FCGR2B蛋白;CD32b蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。