HK1抗体,Mouse Monoclonal HK1 Antibody
  • HK1抗体,Mouse Monoclonal HK1 Antibody
  • HK1抗体,Mouse Monoclonal HK1 Antibody
  • HK1抗体,Mouse Monoclonal HK1 Antibody

HK1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-09
QQ交谈 微信洽谈

产品详情

中文名称:HK1抗体英文名称:Mouse Monoclonal HK1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 315 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: HK1
2025-05-09 HK1抗体 Mouse Monoclonal HK1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 315 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesHKI; HXK1; HK1-ta; HK1-tb; HK1-tc; HK1
Entrez GeneID3098
clone7A7
WB Predicted band size102kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman,Mouse,Rat
ImmunogenPurified recombinant fragment of human HK1 expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Western blot analysis using HK1 mouse mAb against Jurkat (1), Hela (2), HepG2 (3), MCF-7 (4) and PC-12 (5) cell lysate.    


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       Immunofluorescence analysis of NIH/3T3 cells using HK1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Immunohistochemical analysis of paraffin-embedded human salivary gland tissues (left) and kidney tissues (right) using HK1 mouse mAb with DAB staining.    


           

参考文献

以下是关于HK1抗体的参考文献示例(注:文献信息为示例性概括,非真实存在):

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1. **文献名称**:*Hexokinase 1 Expression in Glioblastoma: A Prognostic Marker Revealed by Immunohistochemical Analysis*

**作者**:Wolf A, et al.

**摘要**:本研究通过HK1抗体进行免疫组化检测,发现胶质母细胞瘤组织中HK1蛋白高表达与患者不良预后显著相关,提示HK1可能作为肿瘤代谢重编程的潜在生物标志物。

2. **文献名称**:*Validation of a Novel HK1-Specific Antibody for Flow Cytometry in Metabolic Studies*

**作者**:Smith B, et al.

**摘要**:文章报道了一种新型HK1抗体的开发与验证,证实其在流式细胞术中的高特异性,为研究免疫细胞代谢活性提供了可靠工具。

3. **文献名称**:*HK1 Localization in Alzheimer’s Disease Models: Insights from Subcellular Fractionation*

**作者**:Zhang C, et al.

**摘要**:利用HK1抗体进行Western blot和免疫荧光实验,揭示了阿尔茨海默病模型中HK1蛋白的亚细胞定位异常,提示其与线粒体功能障碍的关联。

4. **文献名称**:*Targeting HK1 in Cancer Metabolism: Therapeutic Implications via Antibody-Based Inhibition*

**作者**:Lee D, et al.

**摘要**:研究通过HK1抗体阻断实验,证明抑制HK1活性可降低癌细胞的糖酵解能力,为靶向代谢的癌症治疗策略提供了实验依据。

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**注**:以上文献信息为基于HK1抗体常见研究方向的模拟概括,实际引用需查询真实数据库(如PubMed)并核实原文。

       

背景信息

**Background of HK1 Antibody**

The HK1 antibody targets hexokinase 1 (HK1), a key enzyme in glycolysis that catalyzes the phosphorylation of glucose to glucose-6-phosphate. As one of four hexokinase isoforms, HK1 is ubiquitously expressed, with high levels in the brain, erythrocytes, and other metabolically active tissues. It is anchored to the outer mitochondrial membrane via an N-terminal hydrophobic domain, enabling its interaction with mitochondrial proteins to regulate energy metabolism and apoptosis.

HK1 plays a critical role in maintaining cellular energy homeostasis and is implicated in pathologies such as cancer, neurodegenerative disorders, and metabolic syndromes. Overexpression of HK1 is observed in many cancers, where it supports the Warburg effect (aerobic glycolysis) to fuel tumor growth. Conversely, HK1 dysfunction is linked to neurodegenerative diseases like Alzheimer’s and Parkinson’s due to disrupted neuronal energy supply.

The HK1 antibody is widely used in research to study protein expression, localization, and molecular mechanisms in disease models. It is validated in applications like Western blot, immunohistochemistry, and immunofluorescence, often with species specificity (e.g., human, mouse, rat). Commercial HK1 antibodies are typically generated using immunogenic peptides from conserved regions of the HK1 protein, with validation via knockout controls or siRNA silencing.

Overall, the HK1 antibody serves as a vital tool for exploring metabolic regulation, disease pathways, and therapeutic targeting in cancer and neurodegeneration.

       
关键字: HK1抗体;HK1;HK1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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