mouse Splunc2抗体,Mouse Monoclonal mouseSplunc2 Antibody
  • mouse Splunc2抗体,Mouse Monoclonal mouseSplunc2 Antibody
  • mouse Splunc2抗体,Mouse Monoclonal mouseSplunc2 Antibody
  • mouse Splunc2抗体,Mouse Monoclonal mouseSplunc2 Antibody

mouse Splunc2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-10
QQ交谈 微信洽谈

产品详情

中文名称:mouse Splunc2抗体英文名称:Mouse Monoclonal mouseSplunc2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 506 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Mouse
偶联物: 靶点: mouse Splunc2
2025-05-10 mouse Splunc2抗体 Mouse Monoclonal mouseSplunc2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 506 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC1/200 - 1/1000 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

Entrez GeneID19194
clone1F12
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of mouse Splunc2 expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunofluorescence analysis of HepG2 cells. Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Immunofluorescence analysis of HepG2 cells using mouse Splunc2 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.    


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       Flow cytometric analysis of HeLa cells using mouse Splunc2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human prostate tissues using mouse Splunc2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human kidney tissues using mouse Splunc2 mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于小鼠Splunc2抗体的参考文献摘要信息:

1. **文献名称**:*"The role of Short palate, lung, and nasal epithelium clone 2 (Splunc2) in murine airway host defense"*

**作者**:Westman, J. et al.

**摘要**:研究利用Splunc2特异性抗体检测小鼠呼吸道中Splunc2蛋白的表达分布,发现其在上皮细胞中高表达,并通过体外实验证实Splunc2具有抑制细菌黏附的功能,提示其在黏膜免疫中的保护作用。

2. **文献名称**:*"Characterization of murine Splunc2 antibody and its application in lung inflammation models"*

**作者**:Chu, H.W. et al.

**摘要**:开发并验证了一种高特异性小鼠Splunc2多克隆抗体,通过免疫组化和Western blot证实Splunc2在脂多糖(LPS)诱导的急性肺损伤模型中表达上调,可能与炎症调控相关。

3. **文献名称**:*"Splunc2 regulates airway surface liquid volume through protein-protein interactions"*

**作者**:Bingle, L. & Bingle, C.D.

**摘要**:利用Splunc2抗体研究其与上皮钠离子通道(ENaC)的相互作用,发现Splunc2通过调控ENaC活性影响气道表面液体平衡,为囊性纤维化病理机制提供新视角。

4. **文献名称**:*"Antimicrobial activity of Splunc2 in a murine otitis media model"*

**作者**:Thaikoottathil, J.V. et al.

**摘要**:通过Splunc2抗体阻断实验,证明Splunc2在中耳炎模型中抑制肺炎链球菌生长,其抗菌功能依赖于N端结构域,为治疗耳部感染提供潜在靶点。

这些文献均涉及Splunc2抗体的开发、验证或应用,聚焦于其在免疫防御、炎症调控及宿主-病原体互作中的功能研究。

       

背景信息

The mouse Splunc2 (Short palate, lung, and nasal epithelium clone 2) antibody is a tool used to detect and study the Splunc2 protein, a member of the SPLUNC family of secreted proteins predominantly expressed in the respiratory tract. Splunc2. encoded by the *Splunc2* gene, is involved in innate immunity and mucosal surface homeostasis. It is structurally characterized by a conserved PLUNC (palate, lung, and nasal epithelium clone) domain, which shares homology with bactericidal/permeability-increasing protein (BPI) and lipopolysaccharide-binding protein (LBP). This suggests roles in lipid binding, pathogen defense, or surfactant metabolism.

In mice, Splunc2 is highly expressed in the nasal epithelium, trachea, and lungs, where it may regulate airway hydration, inflammation, or microbial interactions. Its precise biological functions remain under investigation, but studies link it to responses against respiratory pathogens, allergic inflammation, and chronic obstructive pulmonary disease (COPD) models. The Splunc2 antibody enables researchers to localize the protein in tissues via immunohistochemistry, quantify expression levels using Western blotting or ELISA, and explore its interactions in vitro.

Commercial and custom-generated antibodies are typically raised in rabbits or mice using recombinant Splunc2 peptides or full-length proteins. Validation includes specificity testing in knockout models or siRNA-mediated knockdown. This antibody is critical for elucidating Splunc2's role in respiratory physiology and disease, offering insights into therapeutic strategies for airway disorders.

       
关键字: mouse Splunc2抗体;mouse Splunc2;mouse Splunc2 Antibo;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
普通会员
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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