UCP2抗体

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Immunofluorescence analysis of Hela cells using UCP2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    

  
  

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     Flow cytometric analysis of Hela cells using UCP2 mouse mAb (green) and negative control (red).    

  
  

Uncoupling protein 2 (UCP2) is a mitochondrial inner membrane protein belonging to the anion carrier family, primarily involved in regulating energy metabolism, oxidative stress, and cellular homeostasis. It uncouples oxidative phosphorylation from ATP production, dissipating the proton gradient to generate heat, thereby influencing metabolic efficiency and reactive oxygen species (ROS) modulation. UCP2 is expressed in various tissues, including the brain, pancreas, adipose tissue, and immune cells, and has been implicated in metabolic disorders, cancer, neurodegenerative diseases, and aging.

UCP2 antibodies are essential tools for detecting and quantifying UCP2 expression in research. They enable the study of UCP2's role in metabolic pathways, insulin secretion, inflammation, and cell survival. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Specificity and validation are critical, as UCP2 shares structural homology with other UCP family members (e.g., UCP1. UCP3). High-quality antibodies must distinguish UCP2 from these isoforms and demonstrate minimal cross-reactivity.

Recent studies highlight UCP2's dual role in health and disease, where its upregulation or inhibition can either protect or exacerbate pathologies depending on context. Reliable UCP2 antibodies thus support advancing therapeutic research, particularly in metabolic syndrome, cancer metabolism, and neuroprotection. Researchers prioritize antibodies validated across multiple applications and species to ensure reproducibility in diverse experimental models.