GLP2R抗体,Rabbit Polyclonal GLP2R Antibody
  • GLP2R抗体,Rabbit Polyclonal GLP2R Antibody
  • GLP2R抗体,Rabbit Polyclonal GLP2R Antibody
  • GLP2R抗体,Rabbit Polyclonal GLP2R Antibody

GLP2R抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-11
QQ交谈 微信洽谈

产品详情

中文名称:GLP2R抗体英文名称:Rabbit Polyclonal GLP2R Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1691 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: GLP2R
2025-05-11 GLP2R抗体 Rabbit Polyclonal GLP2R Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1691 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

WB Predicted band size63 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human GLP2R
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: P00401(GLP2R Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P00401(GLP2R Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P00401(GLP2R Antibody) at dilution 1/30. (Original magnification: ×200)    


           

参考文献

以下是3篇关于 **GLP2R抗体** 的参考文献及其摘要概述:

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1. **文献名称**: *"Monoclonal antibodies against the glucagon-like peptide-2 receptor (GLP2R) for tissue-specific targeting"*

**作者**: Yusta B, et al.

**摘要**: 该研究报道了针对GLP2R的单克隆抗体的开发,验证了其在多种小鼠组织(如肠道和脑部)中的特异性结合能力,并展示了其在免疫组化和流式细胞术中的应用潜力。

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2. **文献名称**: *"GLP2R expression in gastrointestinal diseases and its potential therapeutic implications"*

**作者**: Munroe DG, et al.

**摘要**: 本研究利用特异性GLP2R抗体分析胃肠道疾病模型中受体的分布与表达变化,发现GLP2R在肠上皮修复中的关键作用,提示其作为治疗靶点的可能性。

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3. **文献名称**: *"The role of GLP2R in nutrient absorption and intestinal adaptation: Insights from antibody-based studies"*

**作者**: Brubaker PL, et al.

**摘要**: 通过抗体验证GLP2R在肠道细胞中的功能,研究揭示了受体激活后促进营养吸收和肠道适应的机制,为代谢性疾病治疗提供了实验依据。

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如需更详细文献信息,建议通过 **PubMed** 或 **Google Scholar** 搜索上述作者及关键词。

       

背景信息

The glucagon-like peptide-2 receptor (GLP2R) is a G protein-coupled receptor (GPCR) primarily expressed in the gastrointestinal tract, central nervous system, and select endocrine tissues. It binds glucagon-like peptide-2 (GLP-2), a gut-derived hormone involved in intestinal growth, nutrient absorption, and mucosal repair. GLP2R activation triggers signaling pathways like cAMP/PKA, promoting cell proliferation, inhibiting apoptosis, and enhancing barrier function in the gut.

GLP2R antibodies are critical tools for studying receptor localization, expression patterns, and functional roles in physiological or pathological contexts. They enable applications such as immunohistochemistry, Western blotting, and flow cytometry to map GLP2R distribution in tissues or assess its regulation in diseases like short bowel syndrome, inflammatory bowel disease (IBD), or obesity. Commercially available antibodies target specific epitopes (e.g., extracellular or intracellular domains) and vary by species reactivity (human, mouse, rat).

Research using GLP2R antibodies has clarified its therapeutic relevance. For example, GLP-2 analogs (e.g., teduglutide) exploit GLP2R signaling to treat intestinal insufficiency. Dysregulated GLP2R expression is also linked to metabolic disorders and cancer, highlighting its dual roles in homeostasis and disease. However, challenges remain in validating antibody specificity due to GPCR structural homology and low receptor abundance. Recent advances in monoclonal antibody development and epitope tagging have improved detection reliability, supporting deeper mechanistic insights into GLP2R biology.

       
关键字: GLP2R抗体;GLP2R;GLP2R Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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