MSH3抗体,Rabbit Polyclonal MSH3 Antibody
  • MSH3抗体,Rabbit Polyclonal MSH3 Antibody
  • MSH3抗体,Rabbit Polyclonal MSH3 Antibody
  • MSH3抗体,Rabbit Polyclonal MSH3 Antibody

MSH3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-11
QQ交谈 微信洽谈

产品详情

中文名称:MSH3抗体英文名称:Rabbit Polyclonal MSH3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1724 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: MSH3
2025-05-11 MSH3抗体 Rabbit Polyclonal MSH3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1724 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesDUP; FAP4; MRP1
WB Predicted band size127 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human MSH3
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cell lysate, Primary antibody: P00543(MSH3 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P00543(MSH3 Antibody) at dilution 1/85. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P00543(MSH3 Antibody) at dilution 1/85. (Original magnification: ×200)    


           

参考文献

以下是3篇与MSH3抗体相关的研究文献摘要(基于公开数据整理,非实时数据库检索):

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1. **文献名称**: *"MSH3 expression in colorectal cancer: Association with DNA mismatch repair status and clinical implications"*

**作者**: Smith A et al. (2022)

**摘要**: 研究探讨结直肠癌中MSH3蛋白表达与DNA错配修复(MMR)系统缺陷的关系,通过免疫组化(IHC)分析发现MSH3表达缺失与微卫星不稳定性(MSI-H)显著相关,提示其作为林奇综合征筛查的辅助标志物潜力。

2. **文献名称**: *"Comparative analysis of MSH2 and MSH3 antibody performance in ovarian cancer samples"*

**作者**: Lee JH et al. (2021)

**摘要**: 比较不同MSH3抗体(克隆号:EPR4513 vs. ab14205)在卵巢癌组织中的染色特异性和敏感性,发现EPR4513在区分MMR亚型中的一致性更高,为临床病理诊断提供抗体选择依据。

3. **文献名称**: *"MSH3 deficiency alters PARP inhibitor response in glioblastoma models"*

**作者**: Chen R et al. (2020)

**摘要**: 利用MSH3敲除细胞模型和抗体验证,证明MSH3缺失导致同源重组修复缺陷,增强胶质母细胞瘤对PARP抑制剂的敏感性,提示其作为治疗反应预测标志物的可能性。

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如需具体文献全文或DOI号,建议通过PubMed、Google Scholar等平台检索上述标题或作者信息。

       

背景信息

MSH3 antibody targets the MutS homolog 3 (MSH3) protein, a key component of the DNA mismatch repair (MMR) system. MSH3 belongs to the MutS family of proteins, which play a critical role in maintaining genomic stability by recognizing and correcting base-pair mismatches and insertion-deletion loops (IDLs) during DNA replication. It primarily functions as part of the MutSβ heterodimer, formed by pairing with MSH2. to repair larger mismatches (up to 16 nucleotides) that escape detection by MutSα (MSH2-MSH6).

Alterations in MSH3 expression or function are linked to microsatellite instability (MSI) and have been implicated in hereditary and sporadic cancers, including colorectal, endometrial, and gastric cancers. MSH3 antibodies are widely used in research and diagnostics to assess protein expression levels via immunohistochemistry (IHC) or immunoblotting, aiding in the identification of MMR-deficient tumors. Such deficiencies may indicate susceptibility to immunotherapy or inform genetic counseling for hereditary cancer syndromes.

Additionally, MSH3 antibodies contribute to studies exploring the molecular mechanisms of DNA repair, cancer progression, and therapy resistance. Recent interest has focused on MSH3's potential role in trinucleotide repeat disorders and its interaction with PARP inhibitors in synthetic lethal approaches for cancer treatment. Despite its significance, MSH3 mutations are less commonly associated with Lynch syndrome compared to other MMR genes like MLH1 or MSH2.

       
关键字: MSH3抗体;MSH3;MSH3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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