DEGS1抗体,Rabbit Polyclonal DEGS1 Antibody
  • DEGS1抗体,Rabbit Polyclonal DEGS1 Antibody
  • DEGS1抗体,Rabbit Polyclonal DEGS1 Antibody
  • DEGS1抗体,Rabbit Polyclonal DEGS1 Antibody

DEGS1抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-11
QQ交谈 微信洽谈

产品详情

中文名称:DEGS1抗体英文名称:Rabbit Polyclonal DEGS1 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 1915 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: DEGS1
2025-05-11 DEGS1抗体 Rabbit Polyclonal DEGS1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 1915 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/100-1/300 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesMLD; DEGS; DES1; Des-1; FADS7; MIG15; DEGS-1
WB Predicted band size38 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFusion protein of human DEGS1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse small intestine tissue, Mouse skin tissue, Primary antibody: P01285(DEGS1 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P01285(DEGS1 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01285(DEGS1 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于DEGS1抗体的3篇参考文献及其摘要概括:

1. **文献名称**:*DEGS1 variant causes neurological disorder characterized by hypomyelination and mitochondrial dysfunction*

**作者**:Pant DC, et al.

**摘要**:该研究通过全外显子测序发现DEGS1基因突变导致儿童期发病的神经系统疾病,利用DEGS1抗体证实患者细胞中酶活性下降,揭示其影响鞘脂代谢及线粒体功能异常的机制。

2. **文献名称**:*Aberrant DEGS1 expression modulates sphingolipid metabolism in colorectal cancer*

**作者**:Li Y, et al.

**摘要**:研究通过免疫组化(使用DEGS1抗体)发现结直肠癌组织中DEGS1表达升高,其通过调节神经酰胺/鞘氨醇比例促进癌细胞增殖,提示其作为潜在治疗靶点。

3. **文献名称**:*DEGS1-dependent sphingolipid homeostasis in oligodendrocyte differentiation and myelin maintenance*

**作者**:Zhu H, et al.

**摘要**:利用DEGS1敲除小鼠模型和抗体检测,证明DEGS1通过调控特定鞘脂种类影响少突胶质细胞分化及髓鞘稳定性,为脱髓鞘疾病研究提供新视角。

注:以上文献为示例,实际引用时建议通过PubMed/Google Scholar以"DEGS1 antibody"或"DEGS1 sphingolipid"为关键词检索最新研究。

       

背景信息

The DEGS1 antibody targets the enzyme Delta-4-desaturase, sphingolipid 1 (DEGS1), a key player in sphingolipid metabolism. DEGS1 catalyzes the conversion of dihydroceramide to ceramide, a critical step in maintaining sphingolipid homeostasis, which influences cell membrane integrity, signaling, and apoptosis. Dysregulation of DEGS1 is linked to human diseases, particularly hypomyelinating leukodystrophy (HLD18), an inherited neurological disorder caused by biallelic mutations in the *DEGS1* gene. This condition is characterized by impaired myelin formation, leading to developmental delays, motor deficits, and early-onset neurodegeneration.

DEGS1 antibodies are essential tools for studying the enzyme's expression, localization, and function in cellular and disease models. They enable researchers to investigate DEGS1's role in pathologies such as cancer, metabolic disorders, and neurodegenerative diseases. For example, elevated DEGS1 activity has been associated with cancer progression, while reduced levels are observed in certain lipid storage disorders. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to quantify protein levels or visualize tissue-specific expression.

Recent studies also explore DEGS1 as a potential therapeutic target, with its inhibition considered a strategy to modulate ceramide levels in diseases involving sphingolipid imbalance. The development and validation of DEGS1 antibodies thus contribute to both basic research and translational applications, bridging molecular insights with clinical diagnostics and treatment avenues.

       
关键字: DEGS1抗体;DEGS1;DEGS1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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