**Background of DYNLL1 Antibody**
DYNLL1 (Dynein Light Chain 1), also known as LC8. is a highly conserved protein encoded by the *DYNLL1* gene. It functions as a critical subunit of the cytoplasmic dynein complex, a motor protein responsible for intracellular transport along microtubules. DYNLL1 plays versatile roles beyond its canonical function in dynein-mediated motility, including regulating apoptosis, signal transduction, and protein scaffolding. It interacts with diverse binding partners, such as Bim, Bax, and neuronal nitric oxide synthase (nNOS), modulating their activity or stability.
Antibodies targeting DYNLL1 are essential tools for studying its expression, localization, and interactions in various biological contexts. These antibodies are widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunoprecipitation (IP) to investigate DYNLL1's involvement in cellular processes, including mitosis, cargo trafficking, and stress response. Dysregulation of DYNLL1 has been linked to diseases such as cancer, neurodegenerative disorders, and viral infections, underscoring its biomedical relevance. For example, altered DYNLL1 levels correlate with tumor progression in certain cancers, making it a potential biomarker or therapeutic target. Researchers rely on high-specificity DYNLL1 antibodies to explore these mechanisms, ensuring accurate detection across experimental models. Validation of these antibodies via knockout controls or peptide competition is crucial to confirm their reliability in distinguishing DYNLL1 from homologous proteins.