RNH1抗体

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     Flow cytometric analysis of C57BL/6 mouse splenocytes using CD8 Rat mAb and then detected with anti-Rat IgG PE.    

  
  

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     Flow cytometric analysis of Mouse CD8 transfected 293T cells using CD8 mouse mAb and then detected with anti-rat IgG APC .    

  
  

The RNH1 antibody targets Ribonuclease Inhibitor 1 (RNH1), a leucine-rich repeat protein that binds to and inhibits ribonucleases of the RNase A superfamily. RNH1 plays a critical role in maintaining RNA integrity by neutralizing RNase activity, particularly during cellular stress or apoptosis. It is ubiquitously expressed and regulates processes like angiogenesis, RNA metabolism, and immune responses. Dysregulation of RNH1 has been linked to cancer, viral infections, and neurodegenerative diseases, making it a focus of biomedical research.

RNH1 antibodies are essential tools for studying its expression, localization, and interactions. Commonly developed in hosts like rabbits or mice, these antibodies are validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence. Specificity is confirmed using knockout controls or siRNA knockdown. Researchers use RNH1 antibodies to explore its dual role in cancer—acting as both a tumor suppressor (by inhibiting angiogenic RNases) and a potential oncogenic factor in certain contexts. Additionally, they aid in investigating viral mechanisms, as some pathogens exploit RNH1-RNase interactions to evade host defenses. Quality validation parameters, including batch consistency and cross-reactivity checks, ensure reliability in experimental models.