The SNX8 antibody targets Sorting Nexin 8. a member of the sorting nexin (SNX) family involved in membrane trafficking, endosomal sorting, and cellular signaling. SNX proteins typically contain a phox homology (PX) domain that binds phosphoinositides, facilitating their recruitment to specific membrane compartments. SNX8. in particular, is associated with early endosomes and regulates retrograde transport from endosomes to the trans-Golgi network. It also interacts with components of the retromer complex, which mediates cargo sorting and trafficking. Dysregulation of SNX8 has been implicated in neurodegenerative disorders, such as Alzheimer’s disease, due to its role in amyloid precursor protein (APP) processing, and in cancer, where altered membrane trafficking may influence tumor progression.
SNX8 antibodies are essential tools for studying these processes, enabling detection and localization of SNX8 in cells or tissues via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These antibodies are typically developed in hosts like rabbits or mice, with validation for specificity and cross-reactivity across species. Research using SNX8 antibodies has expanded understanding of endosomal dynamics, cargo sorting mechanisms, and disease-related pathways, highlighting their significance in both basic and applied biomedical studies.