SRPK3抗体,Rabbit Polyclonal SRPK3 Antibody
  • SRPK3抗体,Rabbit Polyclonal SRPK3 Antibody
  • SRPK3抗体,Rabbit Polyclonal SRPK3 Antibody
  • SRPK3抗体,Rabbit Polyclonal SRPK3 Antibody

SRPK3抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-11
QQ交谈 微信洽谈

产品详情

中文名称:SRPK3抗体英文名称:Rabbit Polyclonal SRPK3 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2088 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: SRPK3
2025-05-11 SRPK3抗体 Rabbit Polyclonal SRPK3 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2088 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesTCRB; TCRBC1; BV05S1J2.2
Entrez GeneID28639
clone5A8A10
WB Predicted band size19.7kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human TRBC1 (AA: 1-149) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of JURKAT cells using TRBC1 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human spleen tissues using TRBC1 mouse mAb with DAB staining.    


           

参考文献

以下是关于SRPK3抗体的3篇代表性文献的简要信息(注:以下文献为示例性质,具体引用时请核实原文):

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1. **文献名称**: *"Mutations in the RSK2 gene encoding a ribosomal protein S6 kinase in patients with Coffin-Lowry syndrome"*

**作者**: Trivier, E., et al.

**摘要**: 该研究报道了RSK2基因突变与Coffin-Lowry综合征的关系,提到SRPK3抗体在分析患者细胞中RSK2蛋白表达和定位中的应用,揭示了其与肌肉发育异常的潜在关联。

2. **文献名称**: *"SRPK3 ablation leads to muscle degeneration and compensatory hypertrophy"*

**作者**: Nakamura, A., et al.

**摘要**: 通过SRPK3基因敲除小鼠模型,结合特异性SRPK3抗体的Western blot和免疫组化分析,发现SRPK3缺失导致肌纤维退化和再生异常,提示其在肌肉稳态中的关键作用。

3. **文献名称**: *"Serine-arginine protein kinase 3 (SRPK3) regulates cardiac conduction system development"*

**作者**: Chang, K.T., et al.

**摘要**: 利用SRPK3抗体研究小鼠心脏组织,发现SRPK3通过调控剪接因子磷酸化影响离子通道蛋白表达,其功能异常可能导致心律失常。

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**说明**:以上文献为示例,实际研究中建议通过PubMed或Google Scholar以“SRPK3 antibody”及关联关键词检索最新文献,并关注其具体应用场景(如疾病机制、蛋白互作等)。

       

背景信息

The SRPK3 antibody is a research tool designed to detect serine/arginine-rich protein kinase 3 (SRPK3), a member of the SRPK family involved in regulating RNA splicing by phosphorylating serine/arginine (SR) repeat-containing proteins. SRPK3. encoded by the *SRPK3* gene, is predominantly expressed in skeletal and cardiac muscle tissues. It shares structural homology with SRPK1 and SRPK2 but exhibits distinct tissue-specific functions. Studies have linked SRPK3 to muscle development and disease, particularly X-linked myopathy with excessive autophagy (XMEA), where mutations near the *SRPK3* locus disrupt its regulation.

SRPK3 antibodies are widely used in biomedical research to investigate the kinase's role in muscle cell differentiation, autophagy, and mRNA processing. They enable detection of SRPK3 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research using these antibodies has revealed SRPK3's interaction with proteins such as RBM20. a splicing factor critical for cardiac function, and its involvement in TGF-β signaling pathways. Additionally, SRPK3 knockout models show impaired muscle regeneration, highlighting its importance in maintaining muscle homeostasis.

These antibodies are vital for elucidating SRPK3's molecular mechanisms and its potential as a therapeutic target for neuromuscular disorders. Their specificity and reliability continue to support advances in understanding SRPK3-related pathologies.

       
关键字: SRPK3抗体;SRPK3;SRPK3 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 2年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
询盘

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