SLC1A2抗体,Rabbit Polyclonal SLC1A2 Antibody
  • SLC1A2抗体,Rabbit Polyclonal SLC1A2 Antibody
  • SLC1A2抗体,Rabbit Polyclonal SLC1A2 Antibody
  • SLC1A2抗体,Rabbit Polyclonal SLC1A2 Antibody

SLC1A2抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
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产品详情

中文名称:SLC1A2抗体英文名称:Rabbit Polyclonal SLC1A2 Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2617 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: SLC1A2
2025-05-12 SLC1A2抗体 Rabbit Polyclonal SLC1A2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2617 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesEAAT2, GLT-1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human SLC1A2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P03883(SLC1A2 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P03883(SLC1A2 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于SLC1A2抗体的3篇参考文献及其简要摘要:

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1. **文献名称**:*Selective loss of glial glutamate transporter EAAT2 in amyotrophic lateral sclerosis*

**作者**:Rothstein JD, et al.

**摘要**:该研究通过使用SLC1A2(EAAT2)特异性抗体,发现肌萎缩侧索硬化症(ALS)患者的运动皮层和脊髓中EAAT2蛋白水平显著降低,提示谷氨酸转运障碍可能与ALS的神经退行性病变相关。

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2. **文献名称**:*Glutamate transporter EAAT2 expression is up-regulated in astrocytes during postnatal development*

**作者**:Sheldon AL, Robinson MB.

**摘要**:通过免疫组化和Western blot分析,利用SLC1A2抗体证明EAAT2在大鼠脑内星形胶质细胞中的表达随发育阶段逐渐增加,提示其在突触谷氨酸清除中的关键作用。

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3. **文献名称**:*Altered expression of the glutamate transporter EAAT2 in Huntington's disease*

**作者**:Scott HL, et al.

**摘要**:研究采用SLC1A2抗体检测亨廷顿病模型小鼠脑组织,发现纹状体和皮层中EAAT2蛋白表达显著减少,可能与疾病中谷氨酸毒性导致的神经元损伤有关。

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这些文献均通过SLC1A2抗体的实验手段,探讨了该蛋白在神经疾病中的表达变化及其病理意义。如需具体文献年份或期刊,建议通过PubMed/Google Scholar检索标题进一步确认。

       

背景信息

The SLC1A2 antibody targets the solute carrier family 1 member 2 (SLC1A2), a protein encoded by the SLC1A2 gene, also known as excitatory amino acid transporter 2 (EAAT2). This transmembrane protein is predominantly expressed in astrocytes within the central nervous system (CNS) and plays a critical role in regulating extracellular glutamate levels. By transporting glutamate—a major excitatory neurotransmitter—into glial cells, SLC1A2 prevents glutamate-induced neuronal excitotoxicity, maintaining synaptic plasticity and neural homeostasis. Dysregulation of SLC1A2 is implicated in neurodegenerative disorders (e.g., amyotrophic lateral sclerosis, Alzheimer’s disease), epilepsy, and psychiatric conditions.

The SLC1A2 antibody is widely used in neuroscience research to study protein expression, localization, and function in both healthy and diseased tissues. Applications include immunohistochemistry, Western blotting, and flow cytometry. Researchers rely on validated antibodies to ensure specificity, as cross-reactivity with other glutamate transporters (e.g., EAAT1 or EAAT3) may occur. Recent studies also explore SLC1A2’s role in neuroinflammation and its potential as a therapeutic target. However, variability in antibody performance across experimental conditions underscores the need for rigorous validation, including knockout controls, to confirm reliability in diverse models, from cell lines to post-mortem human brain samples.

       
关键字: SLC1A2抗体;SLC1A2;SLC1A2 Antibody;

公司简介

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员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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