HOXB2抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human bladder cancer tissue, Primary antibody: P04936(HOXB2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes    

  
  

**Background of HOXB2 Antibody**

The HOXB2 antibody is a tool used to detect HOXB2. a protein encoded by the *HOXB2* gene, part of the homeobox (HOX) gene family. HOX genes are evolutionarily conserved transcription factors critical for embryonic development, particularly in establishing body segment identity along the anterior-posterior axis. HOXB2. located in the HOXB cluster on chromosome 17. plays roles in neural development, hindbrain patterning, and hematopoiesis.

HOXB2 antibodies are typically developed in hosts like rabbits or mice, using immunogens derived from specific regions of the HOXB2 protein. These antibodies enable researchers to study HOXB2's expression patterns, regulatory mechanisms, and interactions via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF).

Research involving HOXB2 antibodies has highlighted its involvement in developmental disorders and cancers. For example, aberrant HOXB2 expression is linked to leukemia, breast cancer, and neuroblastoma, suggesting roles in cell proliferation and differentiation. Such studies underscore its potential as a biomarker or therapeutic target.

HOXB2 antibodies are essential in unraveling the protein's biological functions and its contribution to disease pathways, bridging developmental biology and oncology research. Their specificity and reliability are validated through knockdown controls or peptide blocking to ensure accurate detection in experimental models.