IL17C抗体,Rabbit Polyclonal IL17C Antibody
  • IL17C抗体,Rabbit Polyclonal IL17C Antibody
  • IL17C抗体,Rabbit Polyclonal IL17C Antibody

IL17C抗体

价格 询价
包装 20μl 50μl 100μl
最小起订量 1μl
发货地 湖北
更新日期 2025-05-12
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产品详情

中文名称:IL17C抗体英文名称:Rabbit Polyclonal IL17C Antibody
品牌: 艾普蒂产地: 武汉
保存条件: Stored at -20°C for 2693 year. Avoid repeated freeze / thaw cycles.产品类别: 抗体
重组: 应用: WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性: Human,Mouse,Rat 宿主: Rabbit
偶联物: 靶点: IL17C
2025-05-12 IL17C抗体 Rabbit Polyclonal IL17C Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武汉 Stored at -20°C for 2693 year. Avoid repeated freeze / thaw cycles. 抗体

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesCX2; IL-17C
WB Predicted band size22 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human IL17C
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A549 cells, K562 cells, Raji cells, human fetal intestine tissue, Primary antibody: P04959(IL17C Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using P04959(IL17C Antibody) at dilution 1/50. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04959(IL17C Antibody) at dilution 1/50. (Original magnification: ×200)    


           

参考文献

以下是关于IL17C抗体的3篇示例参考文献(内容为虚构示例,仅供参考):

1. **文献名称**:*Targeting IL-17C in Psoriasis: A Novel Therapeutic Approach*

**作者**:Schwandner, R. et al.

**摘要**:研究探讨IL-17C在银屑病皮肤炎症中的作用,通过单克隆抗体阻断IL-17C可显著减少角质细胞炎症因子释放,改善小鼠模型症状。

2. **文献名称**:*IL-17C Neutralization Attenuates Intestinal Inflammation in Experimental Colitis*

**作者**:Johnston, A. & Chen, L.

**摘要**:利用抗IL-17C抗体治疗小鼠结肠炎模型,发现其通过抑制Th17细胞活化和肠道屏障修复,显著降低结肠组织炎症水平。

3. **文献名称**:*The Role of IL-17 Family Cytokines in Autoimmunity: Focus on IL-17C*

**作者**:Ramessamy, B. et al.

**摘要**:综述IL-17C在自身免疫疾病中的独特机制,提出靶向IL-17C的抗体相较于其他IL-17成员可能具有更低的感染风险。

4. **文献名称**:*Preclinical Development of a Humanized Anti-IL17C Antibody for Inflammatory Skin Disorders*

**作者**:Genentech Research Group

**摘要**:报道一种人源化抗IL-17C抗体的临床前研究,显示其在银屑病和特应性皮炎动物模型中有效抑制炎症通路并促进表皮愈合。

(注:以上文献为示例,非真实存在,实际研究请通过PubMed或学术数据库查询。)

       

背景信息

IL-17C, a member of the IL-17 cytokine family, is implicated in inflammatory and autoimmune diseases. Unlike other IL-17 family members (e.g., IL-17A/F), IL-17C is primarily expressed by epithelial and barrier tissues in response to pathogens or tissue damage. It binds to a heterodimeric receptor complex (IL-17RA/RE) to activate downstream pro-inflammatory pathways, including NF-κB and MAPK signaling, leading to the production of cytokines, chemokines, and antimicrobial peptides. Dysregulated IL-17C signaling has been linked to chronic inflammatory conditions such as psoriasis, asthma, inflammatory bowel disease (IBD), and atopic dermatitis.

IL-17C-targeting antibodies are therapeutic agents designed to block IL-17C activity. By inhibiting IL-17C binding to its receptor, these antibodies aim to suppress pathological inflammation while preserving other IL-17-mediated protective immune functions. Preclinical studies in murine models demonstrated efficacy in reducing disease severity in psoriasis-like skin inflammation and colitis. Clinical trials of anti-IL-17C antibodies (e.g., MOR106) have shown mixed results, with some trials halted due to insufficient efficacy, highlighting the complexity of IL-17C's role across different diseases.

Current research focuses on identifying patient subpopulations with IL-17C-driven pathology and optimizing antibody design for enhanced specificity. Safety concerns, including potential immunosuppression risks, remain under investigation. IL-17C antibodies represent a promising but challenging avenue for targeted immunomodulation in epithelial-driven inflammatory disorders.

       


关键字: IL17C抗体;IL17C;IL17C Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。
成立日期 2024-06-24 (2年) 注册资本 50万(元)
员工人数 1-10人 年营业额 ¥ 100万以内
主营行业 中间体,化学试剂 经营模式 贸易,工厂,试剂,定制,服务
  • 湖北瑞和宁生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注册资本:50万(元)
  • 企业类型:有限责任公司(自然人投资或控股)
  • 主营产品:中间体。试剂
  • 公司地址:江汉区
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